Publications by authors named "S Temme"
Cardiac fibroblasts are activated following myocardial infarction (MI) and cardiac fibrosis is a major driver of the growing burden of heart failure. A non-invasive targeting method for activated cardiac fibroblasts would be advantageous because of their importance for imaging and therapy. Targeting was achieved by linking a 7-amino acid peptide (EP9) to a perfluorocarbon-containing nanoemulsion (PFC-NE) for visualization by F-combined with H-MRI.
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- - Falls are a major public health issue, especially among older adults (≥60 years) in care settings, leading to serious physical and psychological problems; hence, accurate fall risk assessments are vital for prevention and individualized care.
- - This study evaluated the Fall Risk Score (FRS) using real-world data from 617 elderly individuals in Germany to determine its effectiveness in predicting falls over time and to identify critical threshold values.
- - Results indicated a strong correlation between higher FRS scores and an increased number of falls, particularly in participants with slower gait speeds and those using walking aids, emphasizing the FRS's prognostic validity for fall risk assessment.
Article Synopsis
- * PGLYRP-1 is essential for innate immune response in macrophages when triggered by a specific PGN disaccharide (GMTriP-K), but not by other similar compounds, indicating a unique signaling pathway.
- * The study found that PGLYRP-1 interacts with other proteins in cells, localizes to specific cellular structures, and is involved in regulating gene expression linked to intestinal inflammation in both mice and humans.
Human monocytes can be subdivided into phenotypically and functionally different classical, intermediate and non-classical monocytes according to the cell surface expression of CD14 and CD16. A precise identification and characterisation of monocyte subsets is necessary to unravel their role in inflammatory diseases. Here, we compared three different flow cytometric strategies (A-C) and found that strategy C, which included staining against CD11b, HLA-DR, CD14 and CD16, followed by several gating steps, most reliably identified monocyte subtypes in blood samples from healthy volunteers and from patients with stable coronary heart disease (CHD) or ST-elevation myocardial infarction (STEMI).
View Article and Find Full Text PDFHistological analysis with 2,3,5-triphenyltetrazolium chloride (TTC) staining is the most frequently used tool to detect myocardial ischemia/reperfusion injury. However, its practicality is often challenged by poor image quality in gross histology, leading to an equivocal infarct-boundary delineation and potentially compromised measurement accuracy. Here, we introduce several crucial refinements in staining protocol and sample processing, which enable TTC images to be analyzed with light microscopy.
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