Publications by authors named "S Temam"
Covered Stent Graft for Treatment of Carotid Blowout Syndrome in Patients With Head and Neck Cancer.
JAMA Otolaryngol Head Neck Surg
November 2024
Importance: Carotid blowout syndrome (CBS) is a rare life-threatening complication of head and neck cancer that requires either surgical or endovascular treatment such as a carotid occlusion procedure or stent-graft placement. CBS outcomes and complications of its management using endovascular stent-graft placement remain unclear due to limited published data. Given that this treatment approach is increasingly used, understanding its efficacy and associated risks is paramount.
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- There is currently no reliable biomarker for predicting the effectiveness of EGFR inhibitors in head and neck squamous cell carcinoma (HNSCC), leading researchers to investigate afatinib, a promising treatment.
- In a trial with 61 patients, afatinib showed a high metabolic response, with responders demonstrating specific biomarker expressions (higher pERK1/2 and lower pHER4 and pRB1 levels).
- Further analysis indicated that responders had more tumor-infiltrating B cells, while non-responders had an overrepresentation of NF-kappa B signaling in their gene expression, suggesting potential new biomarkers for afatinib efficacy that require more research.*
Introduction: Subcricoid-hemilaryngopharyngectomy (SCHLP) with a reconstruction using a fasciocutaneous free flap armed with cartilage graft (FFACG) aims to avoid permanent tracheostomy while still maintaining the laryngopharyngeal functions. The purpose of this study is to report the outcome of this surgical approach.
Materials And Methods: Retrospective study including 17 men operated between 2001 and 2019.
Article Synopsis
- The study aimed to create and validate a radiomic model using [F]FDG PET scans to predict overall survival in patients with head and neck squamous cell carcinoma (HNSCC).
- It involved analyzing two datasets of patients treated with afatinib, extracting radiomic features from their PET scans, and using these features alongside clinical data to develop a Cox regression model for predictions.
- The radiomic model showed better performance in predicting survival than clinical models alone, suggesting that combining radiomic features with clinical variables could enhance predictions, though further validation with larger patient groups is needed.
Nutritional support during radiotherapy is crucial to tolerating and completing oropharyngeal squamous cell carcinoma (OPSCC) treatment. The impact of HPV status on nutritional support is debated. The objective was to evaluate the rate of Reactive Feeding Tube (RFT) use and determine its prognostic factors during definitive radiotherapy for OPSCC.
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