Publications by authors named "S Tejiram"
Burn injury results in hypercoagulability and an increased venous thromboembolism risk. However, the most effective chemoprophylaxis for burn-injured patients has yet to be elucidated. Therefore, this study aims to identify the safety and efficacy of a burn center's venous thromboembolism protocol modification which increased the dose of enoxaparin from 40mg daily to 40mg twice daily with peak anti-Xa level adjustments.
View Article and Find Full Text PDFIntroduction: Literature examining the impact of obesity on burn injury remains mixed. Previous examination of the National Burn Repository, now the BCQP, in obesity-related burn research is limited. The aim of this work was to provide an assessment of the BCQP dataset to examine the effect of obesity on burn-related outcomes.
View Article and Find Full Text PDFIntroduction: Plasma inclusive resuscitation (PIR) uses fresh frozen plasma as an adjunct to crystalloid in the management of burn shock and has potential benefits over other colloids. Yet, safety concerns for transfusion-related acute lung injury (TRALI) exist. The aim of this study evaluated the association between TRALI and PIR in a cohort of severely burn-injured patients using the updated Canadian Blood Services Consensus definitions.
View Article and Find Full Text PDFArticle Synopsis
- Dynamically titrated crystalloids are the primary method for treating burn shock, and this study investigates whether adding allogeneic plasma (known as plasma-inclusive resuscitation, or PIR) affects coagulation negatively.
- The study involved 35 patients treated with PIR, analyzing their blood to check for coagulopathy at multiple points during treatment, finding no significant coagulation issues or complications like transfusion reactions.
- Results indicate that PIR does not cause harmful blood clotting changes compared to baseline in burn patients, suggesting it may be safe, but further research is necessary to confirm these results and assess its effectiveness in burn resuscitation.
In recent years, it has become apparent that fibrinolytic dysfunction and endotheliopathy develop in up to 40% of patients during the first hours following thermal injury and are associated with poor outcomes and increased resuscitation requirements. Rapidly following burn injury, the fibrinolytic system is activated, with activation generally greater with increased severity of injury. Very high plasma concentrations of plasmin-antiplasmin complex (marker of activation) have been associated with mortality.
View Article and Find Full Text PDF