Publications by authors named "S Teahan"
To synthesise the evidence comparing the incidence rates of UAS post-RARC vs Open Radical cystectomy (ORC) in adults undergoing cystectomy and to compare differential stricture rates between Extracorporeal and Intracorporeal urinary diversion (ECUD vs ICUD). The primary outcome was incidence rate of UAS post RARC vs ORC and the secondary outcome was incidence rate of UAS in RARC post ECUD vs ICUD. Review authors conducted comprehensive search for studies comparing RARC with ORC in terms of incidence of UAS.
View Article and Find Full Text PDFA 43-year-old woman and a 73-year-old man were referred separately from primary care to the urology service with short histories of frank haematuria. In both cases, histology from transurethral resection of their bladder tumours demonstrated the rare clear cell variant of urothelial/transitional cell carcinoma. Staging scans found the former patient had low-volume local disease, and the latter had locally advanced disease.
View Article and Find Full Text PDFDifferential mechanisms of bicalutamide-induced apoptosis in prostate cell lines.
Prostate Cancer Prostatic Dis
April 2009
Bicalutamide is a non-steroidal antiandrogen used in the treatment of prostate cancer. Although widely accepted as an androgen receptor antagonist, the mechanism by which it induces apoptosis remains unclear. Defining exact pathways by which bicalutamide induces its apoptotic effects would help to advance its clinical applications.
View Article and Find Full Text PDFBackground: PSA measurement is important in prostate cancer detection. However, applying cut-off values of >4 ng/ml as indication for biopsy misses 20-30% of tumours.
Aims: To determine the number of patients with prostate cancer and normal age-related PSA, referred for TRUS biopsy due to abnormal DRE alone.
Article Synopsis
- The study investigates the relationship between the KLK2 gene variants and prostate cancer risk, specifically analyzing five SNPs among 1,251 men with and without prostate cancer.
- Significant associations were found between specific KLK2 SNPs and increased likelihood of prostate cancer, with adjusted odds showing the A allele of KLK2-SNP1 and T allele of KLK2-SNP5 linked to higher risk.
- The research also indicates that certain KLK2 risk genotypes correlate with elevated hK2 serum levels, supporting the idea that KLK2 may contribute to prostate cancer susceptibility through increased hK2 production.