Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths.

Objective: To evaluate whether serum resistin levels are related to cardiovascular risk in obese children.

Design And Methods: Cross-sectional study of 110 children (40 normal weight and 70 severely obese). Clinical and biochemical parameters, including lipid profile, fasting glucose and insulin, and homocysteine, were determined.

Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children.

Objective: To examine vitamin D, parathyroid hormone, and serum calcium-phosphorus levels relationships to biomarkers of oxidative/nitrosative stress, inflammation, and endothelial activation, potential contributors for vascular complications in obese children.

Study Design: Cross-sectional clinical study of 66 obese Caucasian children aged 7 to 14 years. Cardiovascular risk factors were assessed.

Polyamines are increased in obese children and are related to markers of oxidative/nitrosative stress and angiogenesis.

Context: Polyamines (putrescine, spermidine, and spermine) are polycationic amines derived from arginine, which is the precursor of nitric oxide (NO). Due to the close relationship between the metabolism of polyamines and NO metabolism, the alteration in polyamine homeostasis can affect the NO bioavailability at the endothelium.

Objectives: The objective of the study was to test the hypothesis that childhood obesity is associated with a significant modification of blood polyamines and to investigate the presence of correlation between these molecules, circulating markers of oxidative and nitrosative stress, and endothelial dysfunction.

Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation.

Objective: Nitric oxide (NO) is the major endothelium-derived relaxing factor. The aim of the present study was to evaluate NO synthesis and metabolism in severely obese children with different degrees of metabolic risk and to ascertain their relation with the parameters of oxidative stress and inflammation.

Methods: The study involved 60 obese children evaluated with respect to metabolic risk factors (MRFs) (32<4 MRFs and 28 ≥ 4 MRFs) and 50 normal weight children between 7 and 14 years of age.

Elevated advanced oxidation protein products (AOPPs) indicate metabolic risk in severely obese children.

Background And Aims: The assessment of oxidative stress may aid in the identification of subsequent metabolic risk in obese children. The objective of this study was to determine whether the plasma level of advanced oxidation protein products, analyzed with a recently proposed modified assay that involves a delipidation step (mAOPPs), was related to metabolic risk factors (MRFs) in severely obese children.

Methods And Results: The plasma levels of mAOPPs were determined by spectrophotometry in 54 severely obese and 44 healthy children.