Publications by authors named "S Tasca"
This study explored the effects of melatonin on cardiac and vascular function, and redox homeostasis in model PAH. Male Wistar rats were divided into: control (CTR), monocrotaline [MCT (60 mg/kg, single dose i.p)], monocrotaline + sildenafil [MCT + SIL (50 mg/kg/day)], and monocrotaline + melatonin [MCT + MEL (10 mg/kg/day)].
View Article and Find Full Text PDFArticle Synopsis
- Sustained adrenergic overload can lead to harmful changes in the heart, characterized by oxidative stress, which can worsen heart function.
- Boldine (BOL), an antioxidant, was tested for its potential to protect the heart from damage caused by isoproterenol (ISO) in a rat study.
- Results showed that BOL significantly reduced heart enlargement and improved oxidative stress markers compared to ISO alone, suggesting it could be a beneficial treatment for adverse cardiac changes.
Pulmonary arterial hypertension (PAH) is characterised by an increase in mean pulmonary arterial pressure and a compromised the right ventricle (RV), together with progression to heart failure and premature death. Studies have evaluated the role of melatonin as a promising therapeutic strategy for PAH. The objective of this study was to evaluate melatonin's effects on oxidative stress and on the TLR4/NF-kβ inflammatory pathway in the RV of rats with PAH.
View Article and Find Full Text PDFIsoproterenol administration is associated with cardiac inflammation and decreased NO availability. Melatonin has been reported to have cardioprotective effect. The aim of this study was to investigate the effect of melatonin on NO bioavailability and inflammation in myocardial injury induced by isoproterenol.
View Article and Find Full Text PDFBackground: Pterostilbene (PS), a natural and antioxidant polyphenolic compound emerges as a promising intervention in improving the myocardial infarction (MI) damages.
Objetives: This study aimed to evaluate PS actions in promoting redox homeostasis in lungs and right ventricle (RV) of infarcted animals.
Methods: Male Wistar rats (60 day-old) were randomized into three groups: SHAM, MI (infarcted), and MI+PS (MI+pterostilbene).