Oxidative Injury to Lung Mitochondrial DNA is a Key Contributor for the Development of Chemical Lung Injury.

The mechanisms and extent to which inhalation of oxidant gases damage the mitochondrial genome contributing to the development of acute and chronic lung injury have not been investigated. C57BL/6 mice exposed to chlorine (Cl ) gas and returned to room air, developed progressive loss of lung DNA glycosylase OGG1, significant oxidative injury to mtDNA, decreased intact lung mitochondrial (mt) DNA, generation of inflammatory pathway by DAMPs causing airway and alveolar injury with significant mortality. Global proteomics identified over 1400 lung proteins with alteration of key mitochondrial proteins at 24 h post Cl exposure.

The effects of tranexamic acid on the histopathology of defect healing in an porcine model after gastric and colonic endoscopic submucosal dissection.

Introduction: There is limited data on the histopathological effects of hemostatic agents (HAs) used during endoscopic submucosal dissection (ESD). We used an porcine model to compare the tissue effects of tranexamic acid (TXA) and adrenaline (epinephrine) compared to controls.

Methods: Standard ESD, using a 2 mm flash-knife, was performed in three pigs.

Seeking Dental Healthcare in the Context of COVID-19 Pandemic: A Study Examining the Health Belief Model.

Background And Objectives: The main purpose of the study was to examine the factors influencing older adults' seeking dental care, in the context of coronavirus disease 2019 (COVID-19) pandemic, based on the Health Belief Model (HBM).

Research Design And Methods: Phone interviews were conducted using a structured questionnaire, among 200 older adults aged 65 and above, who are members of the Israeli largest sick fund Clalit Health Services, that were sampled through a systematic random sample. The data were collected between January 2022 and March 2022 and during September 2022.

Essential Oil Inhibits the Ability of to Produce Volatile Sulfide Compounds, a Key Components in Oral Malodor.

Oral malodor still constitutes a major challenge worldwide. A strong effort is invested in eliminating volatile sulfur compound-producing oral bacteria through organic natural products such as essential oils. is a known volatile sulfur compound-producing bacteria that inspires oral malodor.