Publications by authors named "S Tange"
When encountering severe hypoxemia that does not respond to oxygen supplementation, it is essential to consider underlying right-to-left shunting. Among various diagnostic approaches, the microbubble test via transthoracic echocardiography (TTE) is a simple, noninvasive method for detecting pulmonary arteriovenous shunts, particularly in hepatopulmonary syndrome (HPS). Although microbubbles are usually administered peripherally, using a Swan-Ganz (SG) catheter to inject microbubbles directly into the pulmonary artery may provide even more definitive diagnostic information.
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- - Acral and mucosal melanomas are more common in Asians compared to Caucasians, while cutaneous melanomas are mainly found in Caucasians; this study focuses on the genetic traits of melanomas in Japanese patients due to under-research in this area.
- - Analysis of 104 Japanese melanoma samples revealed that 94% had driver mutations, with significant mutations differing among melanoma types: BRAF was notable in cutaneous, while acral exhibited mutations in KIT and others, and mucosal showed various driver mutations like NRAS and KRAS.
- - The findings suggest a lower tumor mutational burden in East Asian cutaneous melanoma, potentially impacting the effectiveness of immune checkpoint inhibitors and emphasizing the necessity for personalized treatment strategies based on
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- The study compares two emerging procedures, Balloon Endoscopy-Assisted Endoscopic Retrograde Cholangiopancreatography (BE-ERCP) and Endoscopic Ultrasonography-Guided Biliary Drainage (EUS-BD), for treating malignant biliary obstruction (MBO) in patients with altered surgical anatomy.
- Results show EUS-BD had a significantly higher technical success rate (94%) compared to BE-ERCP (70%), while the clinical success rates and adverse events were similar between the two methods.
- The findings suggest that EUS-BD is more effective than BE-ERCP, particularly in patients with an intact papilla, where BE-ERCP's technical
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- Multiple hereditary infundibulocystic basal cell carcinoma syndrome (MHIBCC) is a genetic disorder linked to SUFU gene mutations, resulting in skin tumors called infundibulocystic basal cell carcinomas (IBCCs).
- A case study of a 57-year-old woman revealed a rare form of mosaic MHIBCC, where a specific SUFU mutation was found in both her tumors and blood, albeit at different frequencies.
- The findings suggest that this mosaicism, along with a loss of heterozygosity on chromosome 10, may lead to a milder presentation of MHIBCC but still carries an increased risk for more severe tumors.
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- A study examined the relationship between the age at diagnosis of intraductal papillary mucinous neoplasms (IPMNs) and the long-term risk of developing pancreatic cancer in a cohort of over 3,000 patients.!
- Results indicated that older patients diagnosed with IPMNs had a significantly increased risk of pancreatic carcinoma, with those aged 75 and older showing the highest risk.!
- The findings suggest that older patients may benefit from regular surveillance to monitor for pancreatic cancer, as targeted monitoring could help reduce cancer-related mortality in this group.!