Publications by authors named "S Tang"

Background: In observational studies, frailty has been strongly associated with mental disorders. However, the mechanisms underlying the association between frailty and mental disorders remain unclear.

Methods: We conducted a two-sample Mendelian randomization (MR) study to assess the causal relationship between frailty, as measured by the frailty index (FI), and ten common mental disorders.

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Peroxynitrite (ONOO) and viscosity are critical indicators of lysosome functionality, intimately linked to numerous diseases' pathophysiological processes. Hence, creating reliable analytical techniques to observe fluctuations in lysosomal ONOO and viscosity is highly important. This study presents the development of a novel naphthalimide-based fluorescent probe, Nap-Cy, specifically designed to target lysosomes and simultaneously detect both ONOO and viscosity.

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In the dorsal striatum (DS), the direct- and indirect-pathway striatal projection neurons (dSPNs and iSPNs) play crucial opposing roles in controlling actions. However, it remains unclear whether and how dSPNs and iSPNs provide distinct and specific contributions to decision-making, a process transforming sensory inputs to actions. Here, we perform causal interrogations on the roles of dSPNs and iSPNs in the posterior DS (pDS) in auditory-guided decision-making.

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Article Synopsis
  • - Treatment of multidrug resistant infections is tough because there aren't many effective antibiotics available, prompting the use of specialized strategies by pharmacists.
  • - A two-part approach is used: in vitro antibiotic combination testing and therapeutic drug monitoring to tailor treatment, similar to precision medicine.
  • - This method showed promising results in two patients with hard-to-treat Acinetobacter baumannii infections, using higher-than-recommended doses without causing any negative side effects.
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