Publications by authors named "S Tamagawa"
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed treatment. We report a successful case of NIR-PIT for post-irradiation locoregionally recurrent oropharyngeal cancer at the tongue base. A 60-year-old man following primary treatment for oropharyngeal cancer at the tongue base by endoscopy (rT1N0M0).
View Article and Find Full Text PDFIntervertebral disc degeneration is a leading cause of chronic low back pain, affecting millions globally. Regenerative medicine, particularly cell-based therapies, presents a promising therapeutic strategy. This study evaluates the comparative efficacy of two biomaterials-hyaluronic acid (HA) and alginate-as carriers for nucleus pulposus (NP) cell transplantation in a beagle model of induced disc degeneration.
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- Exercise-induced laryngeal obstruction (EILO) causes breathing difficulties and stridor during intense activity, but the role of epiglottic retraction in its diagnosis hasn't been fully investigated.
- The study emphasizes the need to assess epiglottic retraction through various diagnostics to improve the accuracy of EILO diagnosis.
- Findings showed epiglottic retraction in some patients during heavy breathing and suggested using laryngoscopy at that time for better detection, especially noting a connection between retraction and lung volume among swimmers.
Cell transplantation is being actively explored as a regenerative therapy for discogenic back pain. This study explored the regenerative potential of Tie2 nucleus pulposus progenitor cells (NPPCs) from intervertebral disc (IVD) tissues derived from young (<25 years of age) and old (>60 years of age) patient donors. We employed an optimized culture method to maintain Tie2 expression in NP cells from both donor categories.
View Article and Find Full Text PDFThe intervertebral disc (IVD) is the largest avascular organ of the human body and plays a fundamental role in providing the spine with its unique structural and biomechanical functions. The inner part of the IVD contains the nucleus pulposus (NP), a gel-like tissue characterized by a high content of type II collagen and proteoglycans, which is crucial for the disc's load-bearing and shock-absorbing properties. With aging and IVD degeneration (IDD), the NP gradually loses its physiological characteristics, leading to low back pain and additional sequelae.
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