Publications by authors named "S Taktak"
Article Synopsis
- Cardiovascular events are a major cause of death in men with advanced prostate cancer, and new treatments like androgen receptor signaling inhibitors (ARSI) may have unknown cardiovascular side effects.
- The study aims to evaluate how the addition of ARSI affects the incidence of cardiovascular events in patients with locally advanced and metastatic prostate cancer.
- A systematic review of 24 studies found that ARSI therapy significantly increases the risk of cardiovascular events, with a risk ratio indicating a higher incidence of both all-grade and severe cardiovascular issues.
The comparability assessment of a biological product after implementing a manufacturing process change should involve a risk-based approach. Process changes may occur at any stage of the product lifecycle: early development, clinical manufacture for pivotal trials, or post-approval. The risk of the change to impact product quality varies.
View Article and Find Full Text PDFObjectives: We sought to evaluate modern diagnostic and treatment options for urachal adenocarcinoma (UAC) and to provide clarity regarding the available options and their outcomes for this poorly understood yet damaging disease.
Material And Methods: We conducted a systematic literature search in PubMed and Medline focusing on updated management of UAC.
Results: Surgical intervention continues to be the mainstay of treatment for localized UAC.