Publications by authors named "S Takebayashi"
Article Synopsis
- The study assessed the effects of prophylactic neck dissection and additional therapy on patients undergoing transoral surgery for hypopharyngeal cancer from 2015 to 2021.
- Out of 221 patients, a high 3-year local recurrence-free survival rate of 89.1% was observed, but positive margins led to higher rates of regional recurrence and distant metastasis, though local recurrence did not affect overall survival.
- The conclusion suggests that monitoring for recurrences is important and that prophylactic neck dissection might not be essential for all patients with positive margins.
Faithful DNA replication is essential for genome integrity. Under-replicated DNA leads to defects in chromosome segregation, which are common during embryogenesis. However, the regulation of DNA replication remains poorly understood in early mammalian embryos.
View Article and Find Full Text PDFObjective: Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy.
Methods: We compared clinical information, surgical complications, and swallowing function in patients who underwent transoral nonrobotic surgery for laryngo-pharyngeal squamous cell carcinoma between 2015 and 2021 in a multicenter retrospective study.
Results: Six hundred and forty patients were included.
In this work, a novel π-extended thio[7]helicene scaffold was synthesized, where the α-position of the thiophene unit could be functionalized with bulky phenoxy radicals after considerable synthetic attempts. This open-shell helical diradical, , possesses high stability in the air, nontrivial π conjugation, persistent chirality, and a high diradical character ( of 0.998).
View Article and Find Full Text PDFPurpose: Mucosal melanoma of the head and neck (MMHN) is a rare condition. This study aimed to investigate oncological outcomes of surgical intervention in patients with MMHN.
Materials And Methods: The study included 34 patients with MMHN who underwent surgical resection as initial treatment at 10 institutions in Japan between July 2005 and June 2015.