Response to pre-dilatation with POBA can predict target lesion revascularization after DCB angioplasty for de novo small coronary artery lesions.

Objective: To assess the determinants of target lesion revascularization (TLR) after drug-coated balloon (DCB) angioplasty for small coronary artery lesions.

Methods: This retrospective study enrolled consecutive lesions from patients that were in a stable condition and had undergone successful DCB treatment for small coronary artery lesions. The study endpoint was TLR and major adverse cardiac events at 12 months.

Reduction and spectroscopic properties of hemoglobins M.

Reduction of five hemoglobins M (Hbs M) was studied using three enzymatic reducing systems; namely NADPH-flavin reductase from human erythrocytes, NADH-cytochrome b5 reductase from human erythrocytes and ferredoxin-NADP reductase from spinach. Under anaerobic conditions, abnormal chains in Hb M Saskatoon were reduced by all three systems, whereas those in Hb M Milwaukee were reduced by the latter two enzyme systems only. The abnormal chains in Hb M Hyde Park were reduced only by the ferredoxin-NADP reductase system.

Ultracytochemistry of pancreatic damage induced by excess lysine.

The ultracytochemical changes induced in the pancreas by a single large dose of lysine (400 mg/100 g body weight) were studied in male Wistar rats of 7 weeks old. The first changes in the acinar cells were marked swelling of mitochondria with increase in their calcium content and decrease in their ATP content. Early calcium deposits seemed to occur in the matrices of swollen mitochondria and later various patterns occurred.