Publications by authors named "S TOVO"
Background: Genetic factors are one of the significant contributors to prostate cancer (PCa) development, and hereditary prostate cancer 2 (HPC2) locus gene ELAC2 is considered a PCa susceptibility region. The HPC2/ELAC2 gene has been identified by linkage analysis in familial prostate cancer patients in the United States but has never been studied in Burkina Faso. The objective of the present study was to analyze the carriage of the C650T (Ser217Leu) and G1621A (Ala541Thr) mutations of the ELAC2 gene and the risk factors in prostate cancer patients in Burkina Faso.
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- Vulvovaginal candidiasis is a significant health issue for women caused by Candida species, with a rising resistance to azole antifungals, particularly linked to mutations in the ERG11 gene.
- A study conducted at Saint Camille Hospital in Burkina Faso found that out of 262 clinical strains, most were C. albicans, with a fluconazole resistance rate of 59.54%.
- The detection of mutated ERG11 in 9.79% of resistant C. albicans strains marks the first report in Burkina Faso and suggests a potential cause for ongoing azole resistance in vulvovaginal infections.
Background: Prostate cancer (Pca) is a public health problem that affects men, usually of middle age or older. It is the second most common cancer diagnosed in men and the fifth leading cause of death. The RNASEL gene located in 1q25 and identified as a susceptibility gene to hereditary prostate cancer, has never been studied in relation to prostate cancer in Burkina Faso.
View Article and Find Full Text PDFViral and bacterial infections represent an occupational risk for female sex workers. This study aimed at determining HPV coinfection with genital pathogens among female sex workers in West and Central Africa and identifying antibiotic resistance genes. A total of 182 samples from female sex workers were analyzed by real-time PCR and classic PCR.
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- The study aimed to explore the link between genetic variations in the GSTM1 and GSTT1 genes and the risk of developing breast cancer in women, involving 80 breast cancer cases and 100 control samples.
- Findings indicated that having a GSTT1-null genotype was associated with a significantly higher risk of breast cancer, while the GSTM1-null genotype showed no such correlation.
- No significant associations were found between these genotypes and breast cancer stage or body mass index, suggesting that only GSTT1-null may contribute to increased breast cancer susceptibility.