Publications by authors named "S TOMASELLI"
Phase I Clinical Trial on Pleural Mesothelioma Using Neoadjuvant Local Administration of Paclitaxel-Loaded Mesenchymal Stromal Cells (PACLIMES Trial): Study Rationale and Design.
Cancers (Basel)
October 2024
Article Synopsis
- Pleural mesothelioma (PM) is a rare cancer closely associated with asbestos exposure, currently lacking effective treatment options, leading to a poor prognosis.
- The study explores using mesenchymal stromal cells (MSCs) to deliver the chemotherapy drug Paclitaxel (PTX) directly to the pleural cavity, aiming to enhance drug concentration at the tumor site while reducing side effects.
- The PACLIMES trial assesses the safety and toxicity of this local PTX administration in patients eligible for surgery, with a goal to identify the effective dose for future studies and evaluate its anti-tumor effects.
Article Synopsis
- There is a significant lack of research on injuries and illnesses in elite luge athletes, prompting this study to analyze their health issues during training and competition periods.
- 40 elite athletes self-reported their injuries and illnesses using a detailed questionnaire, revealing that illnesses were the most common health issue (41.9%), followed by acute injuries (31.9%) and overuse injuries (24.0%).
- The study found that the majority of athletes (95%) experienced at least one health problem, highlighting the urgent need for prevention programs and the establishment of a concussion protocol in the sport.
This study delves into the early aggregation process of the Aβ1-40 amyloid peptide, elucidating the associated oligomers distribution. Motivated by the acknowledged role of small oligomers in the neurotoxic damage linked to Alzheimer's disease, we present an experimental protocol for preparing 26-O-acyl isoAβ1-40, a modified Aβ1-40 peptide facilitating rapid isomerization to the native amide form at neutral pH. This ensures seed-free solutions, minimizing experimental variability.
View Article and Find Full Text PDFBio-polyols (BPOs), characterized by a hydroxyl number up to around 90 mg KOH/g, narrow polydispersity index and relatively low molecular mass up to 2000 g/mol, were synthetized from partially and completely epoxidized soybean and linseed oils and caprylic acid or 3-phenyl butyric acid. These BPOs were used in the presence of toluene diisocyanate to produce polyurethane (PU) foams by using a quasi-prepolymer method involving a two-step reaction. A detailed structural investigation of the prepolymers from toluene diisocyanate and both BPOs and polypropylene glycol was conducted by SEC and solution NMR.
View Article and Find Full Text PDFBackground And Rationale: Novel coronavirus-related disease (COVID-19) has profoundly influenced hospital organization and structures worldwide. In Italy, the Lombardy Region, with almost 17% of the Italian population, rapidly became the most severely affected area since the pandemic beginning. The first and the following COVID-19 surges significantly affected lung cancer diagnosis and subsequent management.
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