Publications by authors named "S T el-Mansoury"

Efficacy of alginate nanoparticles (Alg-NPs) as vaccine delivery for the excretory-secretory antigens (ESAs) against the virulent strain of Toxoplasma gondii was evaluated. Swiss albino mice were intraperitoneally immunized with three doses of either in vivo and in vitro-prepared ESA vaccines, 20 µg each, at 2-week intervals, then were challenged with 2500 tachyzoites of the RH HXGPRT (-) Toxoplasma gondii strain, four weeks later. Mice mortality, tachyzoite number in both peritoneal fluid and impression smear, and viability, ultrastructural tachyzoite changes, measuring immunological markers, and histopathological changes of both liver and spleen were studied, in comparison to alum adjuvanted ESAs and infected control subgroups.

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Introduction And Aim: is a common enteric parasite, having a worldwide distribution. Many antimicrobial agents are effective against it, yet side effects and drug resistance have been reported. Thus, ongoing trials are being conducted for exploring anti- alternatives.

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The present work was designed to assess the effect of different degrees of temperature and salinity on the viability and infectivity of G. lamblia and C. parvum at different storage time.

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Article Synopsis
  • Co-agglutination test (Co-A test) shows potential as a diagnostic tool for detecting T. spiralis antigens in mice, compared to the established ELISA method.
  • Both tests effectively identified the antigens in the urine of infected mice around 30 days post-infection.
  • Co-A test is highlighted as an accurate, easy, and quick method suitable for large-scale testing for trichinellosis.
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Several quinazoline derivatives containing substituted thiosemicarbazido and S-methylisothiosemicarbazido groups at the 2-position and at both the 2- and 4-positions have been synthesized. Treatment of the S-methylthiosemicarbazides with morpholine or diethylamine did not give the corresponding guanidines. Instead, they underwent cyclodesulfurization into the condensed ring systems, [1,2,4]triazolo[4,3-a]quinazolinones and bis-[1,2,4]triazolo[4,3-a:4'.

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