Publications by authors named "S T al-Sedairy"
L. (Safflower) Flower Extract Attenuates Hepatic Injury and Steatosis in a Rat Model of Type 2 Diabetes Mellitus via Nrf2-Dependent Hypoglycemic, Antioxidant, and Hypolipidemic Effects.
Antioxidants (Basel)
September 2024
Article Synopsis
- The study investigated the protective effects of safflower flower extract (SFFE) against liver damage and fat accumulation in a rat model of type 2 diabetes mellitus (T2DM) induced by a high-fat diet.
- SFFE treatment led to significant reductions in blood glucose, cholesterol, and triglyceride levels, improved liver health, and enhanced certain protective pathways in both control and T2DM rats, although it did not lower fasting insulin levels.
- The effects of SFFE were linked to activation of the Nrf2 pathway and inhibition of pro-inflammatory markers, with brusatol blocking these benefits, highlighting its role in liver protection.
: Diabetes mellitus is a chronic metabolic disease associated with several complications, including that of kidney disease. Plant-based dietary products have shown promise in mitigating these effects to improve kidney function and prevent tissue damage. This study assessed the possible favorable effects of beetroot extract (BE) in improving kidney function and preventing tissue damage in diabetic rats.
View Article and Find Full Text PDFWith a variety of symptoms that can impede children's development, food allergies are an important public health concern. With the help of information from the King Fahad Medical City Hospital in Riyadh, we looked at how restricting certain foods affected the growth of Saudi children who had food allergies. An anonymous self-administered questionnaire asking about the individuals' demographics and their restricted eating habits was completed by 72 children (48 boys and 24 girls) between the ages of 2 and 14.
View Article and Find Full Text PDFBackground: Epigenome, genetic variants, and other environmental factors involved in gene regulation are highly inter-dependent in several chronic diseases, including obesity, cardiovascular disease, and diabetes. The present study aimed at testing the associations and the mechanism involved in silencing of CYP2R1 gene in normal and obese Saudi women patients. Height, weight, BMI, 25-hydroxy vitamin D, parathyroid hormone, glycemic status, and lipid profile (TG, LDL, HDL, and TC) of CYP2R1 were measured in 100 women (31 normal and 69 obese patients).
View Article and Find Full Text PDFExposure to allergens could be life-threatening for people with food allergies. Restaurants and cafes are challenging environments for accommodating food allergies. This study aimed to measure King Saud University female students' awareness about food allergens on restaurants' and cafes' menus.
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