Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy.

Cancer immunotherapy often depends on recognition of peptide epitopes by cytotoxic T lymphocytes (CTLs). The tumor microenvironment (TME) is enriched for peroxynitrite (PNT), a potent oxidant produced by infiltrating myeloid cells and some tumor cells. We demonstrate that PNT alters the profile of MHC class I bound peptides presented on tumor cells.

[Enteral tube feeding of patients after esophagoplasty].

A method for enteral catheter feeding is suggested. It was applied in 60 patients after esophagoplasty. The main group consisted of 23 females and 37 males aged from 18 to 68 years.