A SIFT Study of Reactions of Positive and Negative Ions With Polyfluoroalkyl (PFAS) Molecules in Dry and Humid Nitrogen at 393 K.

Rationale: Data are required for SIFT-MS analysis of perfluoroalkyl and polyfluoroalkyl substances (PFAS), which are persistent in the environment and cause adverse health effects. Specifically, the rate coefficients and product ion branching ratios of the reactions of HO, NO, O •, O•, OH, O •, NO and NO with PFAS vapours are needed.

Methods: The dual polarity SIFT-MS instrument (Voice200) was used to generate these eight reagent ions and inject them into the flow tube with N carrier gas at a temperature of 393 K.

State adoption of paid sick leave and cardiovascular disease mortality among adults in the United States, 2008-2019.

Cardiovascular diseases (CVD) are the leading cause of death in the United States and may be prevented through improved working conditions. The United States does not guarantee paid sick leave (PSL) at the federal level. We used quasi-experimental event study methods to examine the relationship between state-level PSL policies and county-level CVD mortality among working-age adults aged 15 to 64 over time (2008 to 2019).

Protocol for quantifying murine cardiomyocyte cell division by single-cell suspension.

The cardiac regeneration and development fields lack low-barrier-to-entry techniques that distinguish cardiomyocyte division from alternative outcomes in vivo. Here, we present a protocol in rodents to determine if cardiomyocyte cell division has occurred. We describe thymidine analog administration, Langendorff procedure, immunofluorescent labeling, microscopy, and analysis of fluorescent images to assess ploidy, thereby allowing an investigator to retrospectively claim cell division.

Polydopamine-Mediated Antimicrobial Lipopeptide Surface Coating for Medical Devices.

Biofilm formation on medical implants such as catheters is a major issue which needs to be addressed as it leads to severe health care associated infections. This study explored the design and synthesis of a polydopamine-lipopeptide based antimicrobial coating. The coating was used to modify the surface of Ultrathane Catheters.

Selected ion flow tube studies of the reactions of HO, NO, O˙ and O˙ ions with alkanes in He and N carrier gases at different temperatures.

The kinetics of the reactions of HO, NO, O˙ and O˙ with -hexane, 3-methylpentane, 2,5-dimethylhexane and 2,3-dimethylheptane were studied experimentally under several selected ion flow tube (SIFT) conditions: in a Profile 3 instrument in He and N carrier gases at 300 K and in the Voice200 instrument in N carrier gas at 300 and 393 K - where the effect of the extraction lens voltage was also assessed. It was found that HO ions react differently than expected, with reaction rates slower than collisional. Instead of transferring a proton, they associate and form fragment product ions [M-H].