Publications by authors named "S T Sonis"
Background: The variability in patients' risk of oral mucositis (OM) has been, in part, attributed to differences in host genomics. The aim better define the role of genomics as an OM risk by investigating the association between genetic variants and the presence and severity of OM in pediatric patients with osteosarcoma (OS) undergoing chemotherapy (CT).
Methods: A longitudinal observational retrospective study was conducted.
The oral medicine workforce and impact on access to care in the United States.
Oral Surg Oral Med Oral Pathol Oral Radiol
December 2024
Objectives: The objective of this study was to characterize the current oral medicine (OM) workforce by examining the distribution of OM diplomates (OMDs) across the Unites States and to determine the need for expanding access to care.
Study Design: The OMD access was calculated based on the OMDs per 10,000 state population from the 2020 US Census data as well as their distance from state capitals and most populated cities. OMD penetrance in hospitals and cancer centers was assessed at National Cancer Care Network (NCCN) cancer centers, and Best Hospitals as reported in the 2022 US News and World Report (USNWR).
Background: Barrier films or dressings were reported to be effective in preventing radiation dermatitis (RD) in breast cancer patients, but their comparative efficacy is unknown.
Methods: A systematic literature search was performed on Embase, MEDLINE and Cochrane CENTRAL Registry of Clinical Trials from inception to October 20, 2023. Randomised controlled trials (RCTs) comparing barrier films or dressings to the standard of care (SOC) or other interventions were included.
Financial Burden of Dental Care Among Patients With Head and Neck Cancer.
JAMA Otolaryngol Head Neck Surg
September 2024
Importance: Patients undergoing treatment for head and neck cancer (HNC) experience oral complications requiring substantial dental treatment. This treatment is commonly not reimbursed by medical insurers, presenting a potential financial burden for patients.
Objective: To characterize the dental care needs and associated cost burden for patients with HNC.
Article Synopsis
- Oral mucositis (OM) is a serious side effect for patients undergoing radiotherapy or chemoradiotherapy for head and neck cancers, leading to increased interest from the pharmaceutical industry in finding an effective treatment.
- A study examined the features of successful and failed Phase III trials by analyzing aspects such as sponsor funding, patient criteria, and consistency in efficacy outcomes across trial phases.
- The research identified three successful trials (involving avasopasem manganese and palifermin) and three unsuccessful ones (dusquetide, iseganan hydrochloride, and clonidine), highlighting the importance of specific trial design elements for better outcomes in future studies.