Publications by authors named "S T Pierson"
Purpose: Advances in fetal fraction amplification in prenatal cell-free DNA screening now allow for high-resolution detection of copy-number variants (CNVs). However, approaches to interpreting CNVs as part of a primary screen are still evolving and require consensus. Here, we present a conservative, patient-centered framework for reporting fetal CNVs.
View Article and Find Full Text PDFPurpose: Clinically significant copy-number variants (CNVs) occur in 1% to 2% of pregnancies and are difficult to detect via prenatal cell-free DNA (cfDNA) screening because of the low fraction of fetal-derived cfDNA in maternal plasma. Here, we use fetal fraction amplification (FFA) and improved computational algorithms to enhance the resolution and sensitivity of CNV detection.
Methods: We implemented and characterized the performance of a hidden Markov model that identifies fetal CNVs.
Candida auris is a growing concern due to its resistance to antifungal drugs, particularly amphotericin B (AMB), detected in 30 to 60% of clinical isolates. However, the mechanisms of AMB resistance remain poorly understood. Here we investigated 441 in vitro- and in vivo-evolved C.
View Article and Find Full Text PDFArticle Synopsis
- Antifungal drug resistance is a significant global health issue, prompting the need for new treatment strategies that involve understanding collateral sensitivity and cross-resistance in pathogenic fungi.
- A study on Candida auris revealed that using collateral sensitivity-based drug cycling can effectively prevent drug resistance from developing and can help eliminate resistant sub-populations.
- The findings indicate that incorporating collateral sensitivity into treatment decisions could lead to better antifungal therapies, as certain sensitivity trends appear consistent across different strains and resistance mechanisms.
Histotripsy-induced bactericidal activity correlates to size of cavitation cloud in vitro.
IEEE Trans Ultrason Ferroelectr Freq Control
October 2024
Article Synopsis
- * Researchers aim to use therapeutic ultrasound, specifically a technique called histotripsy, as a noninvasive way to destroy bacteria within these abscesses.
- * The study found a strong link between the size of the cavitation cloud produced during histotripsy and the effectiveness of bacterial inactivation, indicating promising potential for this ultrasound method.