Publications by authors named "S T Phan"
Tubulocystic renal cell carcinoma (TC-RCC) is uncommon and is defined by exclusive tubulocystic growth. Its clinicopathology is still evolving. Twenty-eight cases of so-defined TC-RCC were studied for clinicopathology as well as, in some cases, immunohistochemistry.
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- The increasing number of Canadians over 65 years old highlights the need for smart home technologies to help manage chronic diseases and support independent living among older adults.
- This systematic review evaluated the clinical evidence for various in-home localization technologies, reviewed their acceptability, and categorized the types of technologies available.
- Findings showed mixed results regarding the ability of these technologies to identify cognitive impairments, though they were effective in detecting frailty; acceptability was generally favorable, particularly for ambient sensors, with high accuracy levels for room detection.
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- The structure of DNA, particularly its double-helix formation, is crucial for understanding how genetic information is stored, copied, and organized in the nucleus of mammalian cells.
- ChromEMT is a new method developed to visualize and reconstruct the 3D organization and interactions of DNA and nucleosomes, enabling researchers to study chromatin structures and their roles in DNA replication, gene expression, and cell fate.
- The ChromEMT process involves a detailed protocol that includes staining DNA with a fluorescent dye, photo-oxidation, and sample preparation, requiring around 9 days and expertise in electron microscopy techniques.
Sacituzumab govitecan (SG), a Trop-2-directed antibody-drug conjugate, is approved for patients with metastatic triple-negative breast cancer (mTNBC) who received ≥2 prior systemic therapies (≥1 in metastatic setting). Exposure-response (E-R) relationships between SG exposure and efficacy and safety outcomes were characterized in 277 patients with mTNBC using data from the phase I/II IMMU-132-01 and phase III ASCENT (IMMU-132-05) studies. Evaluated endpoints included complete response (CR), objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and safety endpoints (individual first worst grade of select adverse events (AEs)).
View Article and Find Full Text PDFThe confinement method is a reaction coordinate-free enhanced sampling method for the calculation of conformational free energy differences. We show that in explicit solvent, artifacts occur when treating charged solutes. These artifacts are resolved by switching off the particle mesh Ewald (PME) method at the start of confinement.
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