[EXPERIMENTAL GROUNDS ON POSSIBILITY TO MAKE AND TO USE PREDICTION MODELS OF PESTICIDES DESIGN STANDARD IN THE WATER OF PONDS USED FOR HOUSEHOLD AND DRINKING WATER SUPPLY].

Taking into account the fact that current calculation methods for substantiation of standards in the water of water reservoirs valid in Ukraine are outdated the aim of our research was to scientifically substantiate the possibility to make and to use prediction models of pesticides design standard in the water of ponds used for household and drinking water supply. Array of experimentally substantiated and approved to use in Ukraine maximum allowable concentrations (MAC) of organic pesticides active ingredients in the water was analyzed (n = 201). Analysis of dependence between MAC value of pesticides in the water and its physical and chemical properties, indices of ecotoxicological hazard and persistency in the water was carried out using correlation and regression analysis methods.

[Biochemical parameters of blood and morpho-functional state of the liver of experimental animals by the actions of lead sulfide nanoparticles in different time study].

Biochemical studies revealed that alanine aminotransferase levels changing first during short action (30 injections) of lead sulfide nanoparticles of size 10 and 30 nm, and the ionic form of a 400 nm lead while the growth of both enzymes (aspartate aminotransferase and alanine aminotransferase) activity during long-term exposure (60 injections) is the same intensity. It it confirmed by the value of de Ritis coefficient, which is statistically the same as control. Morphological studies also confirm these data--degenerative changes of hepatocytes, reactive changes of the stroma and vascular responses were detected.

[Cumulative risk assessment for consumers of agricultural crops polluted with one chemical class pesticide residues (case of triazole fungicides)].

Different indices of cumulative risk assessment of combination of residues of pesticides which may simultaneously be present in raw agricultural crops, based on toxic evaluation of such combination have been presented. Risk for population health due to consumption of raw agricultural crops with triazole residues is acceptable on hazard index, point of departure index and cumulative risk index, exceeds allowable level on criterion "total margin of exposure".

[Experience gained with the training of interns-hygienists and its use in creating the structure of an integrated licensing examination "Step 3 - Sanitary-Hygienist Work"].

The experience gained with the training of interns-hygienists at the National Medical University has proved its value, contributing to which fact were modern material-and-technical resources, close cooperation of chairs of hygiene with sanitary epidemiologic stations and scientific-research institutes, highly skilled scientific and teaching personnel, systematic sharing of experience gained in training of specialists with institutions of higher learning of Ukraine. However, interns, Masters, practitioners are still in great need of modern educational literature/training aids. There has not yet been developed a general concept of structure of sanitary epidemiological service of Ukraine, forms and methods of its work under present-day conditions.