Publications by authors named "S T Grey"
Article Synopsis
- This study aims to enhance prediction of patient outcomes after severe traumatic brain injury (sTBI) by integrating clinical data with serum inflammatory and neuronal protein levels.
- Researchers enrolled 53 adult patients and used machine learning techniques to develop models predicting post-traumatic vasospasm (PTV) and mortality, identifying specific biomarkers and clinical signs as key predictors.
- Findings reveal that certain inflammatory markers and demographic factors can better predict PTV development and mortality than standard clinical tools, indicating the importance of biochemical data in assessing sTBI outcomes.
Understanding the molecular mechanisms of differentiation is important for regenerative medicine and developmental biology. This study aims to characterise the role of the glycolysis/oxidative phosphorylation balance as a driver of mesenchymal stem cell (MSC) differentiation. Cells were maintained in normal conditions or stimulated towards the MSC trilineage cell types over 21 days.
View Article and Find Full Text PDFAim: To use autofluorescence multispectral imaging (AFMI) to develop a non-invasive assay for the in-depth characterisation of human bone marrow derived mesenchymal stromal cells (hBM-MSCs).
Methods: hBM-MSCs were imaged by AFMI on gridded dishes, stained for endpoints of interest (STRO-1 positivity, alkaline phosphatase, beta galactosidase, DNA content) then relocated and results correlated. Intensity, texture and morphological features were used to characterise the colour distribution of regions of interest, and canonical discriminant analysis was used to separate groups.
Objective: To propose a rational basis for donor testing in cases of suspected antibody-mediated transfusion-related lung injury (AMT).
Background: Anti-leukocyte antibodies in donated blood are established causes of transfusion-related lung injury (TRALI). However, the question of whether to test donors for antibodies is not identical to whether the case meets definition criteria for TRALI.
A combination of improved body armor, medical transportation, and treatment has led to the increased survival of warfighters from combat extremity injuries predominantly caused by blasts in modern conflicts. Despite advances, a high rate of complications such as wound infections, wound failure, amputations, and a decreased quality of life exist. To study the molecular underpinnings of wound failure, wound tissue biopsies from combat extremity injuries had RNA extracted and sequenced.
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