Publications by authors named "S T Goebel"
Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and often accompanied with debilitating pathologies including seizures and hyperactivity. FXS arises from a trinucleotide repeat expansion in the 5' UTR of the gene that silences expression of the RNA-binding protein FMRP. Despite progress in understanding FMRP functions, the identification of effective therapeutic targets has lagged and at present there are no viable treatment options.
View Article and Find Full Text PDFUnlabelled: Recombinant chimeric horsepox virus (TNX-801) is a preclinical vaccine in development against mpox and smallpox. In this report, we investigated the potential phenotypic differences in and models between TNX-801 and older vaccinia virus (VACV)-based vaccine strains (VACV-Lis and VACV-NYCBH) used in the eradication of smallpox as well as VACV-WR, VACV-IHD, and MVA. TNX-801 displayed a small plaque phenotype (~1-2 mm) in BSC-40 and Vero-E6 cells.
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- The study aimed to explore the emotional health of parents caring for children with shunted hydrocephalus and to see if psychological issues were linked to caregivers' backgrounds and children's clinical conditions.
- Conducted in outpatient settings at two German hospitals, the research involved administering various psychological questionnaires to 63 parents, assessing levels of depression, anxiety, psychosocial distress, and concerns related to their children's illness.
- The results revealed that 60% of parents experienced significant mental health issues, with no connections to demographic factors or children's clinical issues, but a strong correlation was found between parents' worries and their psychological distress.
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- Platelets, through their glycoprotein VI (GP VI) receptor, significantly influence the development and progression of abdominal aortic aneurysm (AAA), a dangerous cardiovascular disease.
- In experimental studies with mice, the deletion of GP VI resulted in less aortic expansion and reduced inflammation, showing that it plays a crucial role in AAA pathology.
- The findings suggest that GP VI could serve as a potential biomarker for early detection of AAA in patients, as well as a target for future therapeutic interventions.
The thyroid in Graves' disease undergoes a considerable divergence in size and position from the normal anatomy. However, knowledge of the pathological anatomy related to the change, which is required before planned surgical or local intervention, or diagnosis, is neglected. To investigate Graves' disease, we established a model of mice that successfully mimicked all the signs presented in the clinic.
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