Reactivity of canonical bacterial cytochrome peroxidases: insights into the electronic structure of compound I.

Bacterial cytochrome peroxidase (bCcP) family members include di-heme enzymes that are capable of producing various high oxidation states in their reactions with the substrate HO. Canonical family members such as the enzyme from () are responsible for the detoxification of HO in the periplasm of many Gram negative organisms. Elucidation of the electronic structure of the kinetic intermediates for canonical bCcP enzymes has yet to be attained, though the orthologs MauG and others have evoked a Fe(iv)Fe(iv)[double bond, length as m-dash]O species capable of long-range oxidation.

Urethral Stricture Symptom and Impact Measure (USSIM) Validation Study.

Objective: To create and validate a disease-specific Patient-Reported Outcome Measure (PROM) derived from the patient voice for men with a urethral stricture disease.

Methods: We previously performed and published a qualitative assessments to construct a disease-specific PROM for urethral stricture disease. Psychometric evaluations were done on the developed final form using both the preoperative and postoperative data.