Alprazolam decreases isoproterenol induced myocardial damage in the rat.

Myocardial trauma and damage were induced by two doses of isoproterenol 40 mg.kg-1 in rats. Isoproterenol injections alone caused the expected cardiotoxicity.

Resuscitation fluid composition and myocardial performance during burn shock.

The present study examines the effects of resuscitation fluid composition on myocardial function, myocardial high-energy phosphate content, and survival following third-degree anesthetic burn to 35-40% body surface area in the guinea pig. Treatment regimens used were 1) no resuscitation, 2) isotonic saline, 3) Ringer's lactate and 4) Ringer's acetate. Fluids were administered at the rate of 0.

The effect of diazepam administration on heart rate and mean arterial blood pressure in resting and stressed conscious rats.

In unstressed rats, doses of 1 mg/kg and higher of diazepam produced tachycardia without changing blood pressure. Sub-chronic dosing (10 mg/kg/day for 4 days) resulted in increased magnitude and duration of the tachycardia. This diazepam induced tachycardia was unaffected by reserpine, slightly blocked by propranolol and abolished by atropine pretreatment.

Effect of decapitation and stress on some plasma electrolyte levels in rats.

Male Sprague-Dawley rats carrying indwelling jugular catheters were used to compare two methods of blood collection, catheterization or decapitation, for obtaining the plasma levels of several electrolytes. Decapitation resulted in higher levels of Ca2+, Mg2+, and K+ (18%, 23%, and 35% respectively) compared to catheter values. In a second experiment, catheterized rats were used to examine the effect of immobilization and footshock on plasma electrolytes.