Publications by authors named "S T Case"
Chimeric antigen receptor (CAR)-T cell therapy represents a breakthrough for the treatment of hematological malignancies. However, to treat solid tumors and certain hematologic cancers, next-generation CAR-T cells require further genetic modifications to overcome some of the current limitations. Improving manufacturing processes to preserve cell health and function of edited T cells is equally critical.
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- - Energy flow in brain cells is complex and not fully understood, especially in relation to aging and neurodegenerative diseases, which could benefit from studying single-cell bioenergetics.
- - The study used mixed cultures of neurons and astrocytes to analyze energy status with a specialized nanosensor (PercevalHR) while exposing cells to various compounds such as KCl, glutamate, FCCP, insulin, and glucose.
- - Results showed that PercevalHR effectively tracked energy changes in both cell types, with KCl, glutamate, and FCCP causing significant fluctuations, while insulin and glucose influenced energy status more subtly, possibly indicating their role in brain insulin sensitivity.
Objective: Autoantibodies and autoimmune diseases after SARS-CoV-2 infection are widely reported. Given evolving variants, milder infections, and increasing population vaccination, we hypothesized that SARS-CoV-2 infection earlier in the pandemic would be associated with more autoimmune connective tissue disease (CTD) symptoms and immunologic abnormalities.
Methods: Patients ≥18 years old with COVID-19 3/1/2020-8/15/2022 completed the CTD Screening Questionnaire and were tested for 27 autoimmune serologies, SARS-CoV-2 serologies, cell-bound complement activation products (CB-CAPs), and T and B lymphocyte immunophenotypes by flow cytometry.
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- - The pediatric Glucocorticoid Toxicity Index (pGTI) is a tool developed to measure the negative effects of glucocorticoids on children's health, specifically in those with pediatric-onset systemic lupus erythematosus (pSLE).
- - A study of 126 pSLE patients over several years found that many experienced significant toxicity, with the most frequent issues being high blood pressure (47%), mood disturbances (25%), and weight gain (21%).
- - The findings suggest that younger age, higher BMI, and the use of rituximab when beginning glucocorticoid treatment may increase the risk of cumulative toxicity, highlighting the need for tailored assessments to improve treatment strategies for
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- Khat is a plant that many people in eastern Ethiopia use as a stimulant, and its use has grown a lot, even though it can have bad effects on health.
- Researchers talked to people in the Haramaya District to learn how they feel about khat and how it affects their lives.
- The study found that khat is seen as important for making money, can mess with markets, and is tied to people’s relationships, showing how its use has changed from traditional to more practical reasons for making a living.