Active plasma sterilizer for planetary protection and contamination control for space missions.

This paper introduces a novel, compact plasma sterilization system, the Active Plasma Sterilizer (APS), for planetary protection space missions. The development of the APS system is done through iterative testing and design modifications aimed at addressing decontamination modalities for time and temperature, cleaning adhesive surfaces, and cleaning protocols beyond alcohol and bleach. Decontamination testing of Deinococcus radiodurans, Geobacillus stearothermophilus (spore forming bacteria), and Aspergillus fumigatus (fungi) was verified for the APS on relevant materials of 4 to 5 log reduction up to complete killing in 45 min or less.

Effect of Medium Chain Triglycerides and Whey Protein Isolate Preloads on Glycaemia in Type 2 Diabetes: A randomised crossover study.

Background: Small nutritional preloads can reduce postprandial glucose excursions in individuals with and without metabolic syndrome or T2D. However, most studies have focused on preloads administered before single meals and have predominantly used protein-based preloads.

Objective: To investigate the effects of sequential consumption of medium chain triglycerides (MCT) and whey protein isolate (WPI) preloads before breakfast lunch and dinner on postprandial, diurnal and 24h glycaemia in individuals with T2D.

Hybrid Service Delivery for voluntary, community and social enterprise organisations working with adults with learning disabilities and/or autism: a realist review protocol.

Background: Delivery of health and care services using a combination of remote and/or in-person channels and digital and/or traditional tools (Hybrid Service Delivery, HSD) is increasingly seen as a way of improving quality and affordability, improving access, personalisation and sustainability, and reducing inequalities. Across the voluntary, community and social enterprise sector (VCSE), using a combination of remote and/or in-person channels and digital and/or traditional tools (HSD) has enabled the essential provision of services for people who have learning disabilities and/or autistic (LDA). However, it is unclear how different tools and channels have been used, what worked well or not well, for whom, and in what circumstances.

Pelvis Or Involved Node Treatment: Eradicating Recurrence in Prostate Cancer (POINTER-PC) - study protocol paper for a phase III multicentre, open-label randomised controlled trial.

Introduction: Prostate cancer (PCa) is the most common cancer in men. Recurrence may occur in up to half of patients initially treated with curative intent for high-risk localised/locally advanced PCa. Pelvic nodal recurrence is common in this setting, but no clear standard of care exists for these patients, with potential therapeutic approaches including stereotactic body radiotherapy (SBRT) to the involved node(s) alone, extended nodal irradiation (ENI) to treat sites of potential micrometastatic spread in addition to involved node(s) and androgen deprivation therapy with or without additional systemic anticancer therapies.