Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals.

The analysis of circulating tumour DNA (ctDNA) through minimally invasive liquid biopsies is promising for early multi-cancer detection and monitoring minimal residual disease. Most existing methods focus on targeted deep sequencing, but few integrate multiple data modalities. Here, we develop a methodology for ctDNA detection using deep (80x) whole-genome TET-Assisted Pyridine Borane Sequencing (TAPS), a less destructive approach than bisulphite sequencing, which permits the simultaneous analysis of genomic and methylomic data.

Empowering Older Adults With Mobile Device Reminders for Medication Adherence.

Medication adherence in older adults is a growing concern and is a critical element in treating chronic diseases. This pilot study aimed to assess the impact of a mobile device reminder on medication adherence in those aged 60 and over. Initiating the mobile reminder proved to be beneficial in increasing medication adherence.

Comparative Study of Polyethylene, Polypropylene, and Polyolefins Silyl Ether-Based Vitrimers.

Polyolefins (POs), which constitute over 50% of all plastics, predominantly end up in landfills. To date, there have been no reports on mixtures of PO vitrimers. This study reports the successful synthesis of PO vitrimers from a mixture of 27.

Effect of Common Medications on Longitudinal Pectoralis Muscle Area in Smokers.

Background: Cigarette smoke contributes to skeletal muscle wasting. While exercise and nutritional therapies are effective in improving skeletal muscle quantity and quality, the effect of medications on longitudinal muscle loss is unclear. We investigated whether long-term use of common medications affects longitudinal skeletal muscle changes in current and former smokers.

Transportable, portable, wearable and (partially) implantable haemodialysis systems: comparison of technologies and readiness levels.

Background: Dialysis modalities and their various treatment schedules result from complex compromises ('trade-offs') between medical, financial, technological, ergonomic, and ecological factors. This study targets summarizing the mutual influence of these trade-offs on (trans)portable, wearable, or even (partially) implantable haemodialysis (HD) systems, identify what systems are in development, and how they might improve quality of life (QoL) for patients with kidney failure.

Methods: HD as defined by international standard IEC 60601-2-16 was applied on a PUBMED database query regarding (trans)portable, wearable, and (partly) implantable HD systems.