Coacervation in Slow Motion: Kinetics of Complex Micelle Formation Induced by the Hydrolysis of an Antibiotic Prodrug.

Colistin methanesulfonate (CMS) is the less-toxic prodrug of highly nephrotoxic colistin. To develop and understand highly necessary new antibiotic formulations, the hydrolysis of CMS to colistin must be better understood. Herein, with the addition of poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMAA) to CMS, we show that we can follow the hydrolysis kinetics, employing small-angle X-ray scattering (SAXS) through complex coacervation.

Tuneable Plasmonic Resonances Of A Dynamic Thin Film Of Ultrasmall Nanocrystals Modified In the Anti-Galvanic Reduction Process.

Ultrasmall gold nanoparticles (NPs) have revolutionized nanotechnology as they are an excellent starting substrate for the synthesis of organic-inorganic hybrid materials with photonic or energy conversion applications, often with a responsive nature. However, ultrasmall NPs do not sustain plasmonic resonances, preventing their use in plasmon-related applications. In the presented work, we show a method of chemical modification of ultrasmall gold nanoparticles in order to fabricate dynamically controlled plasmonic thin films.

Stability of Nanopeptides: Structure and Molecular Exchange of Self-assembled Peptide Fibers.

Often nanostructures formed by self-assembly of small molecules based on hydrophobic interactions are rather unstable, causing morphological changes or even dissolution when exposed to changes in aqueous media. In contrast, peptides offer precise control of the nanostructure through a range of molecular interactions where physical stability can be engineered in and, to a certain extent, decoupled from size via rational design. Here, we investigate a family of peptides that form beta-sheet nanofibers and demonstrate a remarkable physical stability even after attachment of poly(ethylene glycol).

Photonic Integrated Interrogator for Monitoring the Patient Condition during MRI Diagnosis.

In this work, we discuss the idea and practical implementation of an integrated photonic circuit-based interrogator of fiber Bragg grating (FBG) sensors dedicated to monitoring the condition of the patients exposed to Magnetic Resonance Imaging (MRI) diagnosis. The presented solution is based on an Arrayed Waveguide Grating (AWG) demultiplexer fabricated in generic indium phosphide technology. We demonstrate the consecutive steps of development of the device from design to demonstrator version of the system with confirmed functionality of monitoring the respiratory rate of the patient.

[Factors influencing the hormonal function in patients after the treatment of larynx cancer].

It has been revealed that the hypothyreosis (subclinical as a rule) can be found after every method applied in treatment of the larynx cancer. Correlation of data obtained with the time function allowed to specify survival probability of patients in euthyreosis after therapy termination. Among the factors supposed to be involved in keeping patient's normal thyroid gland function the following have been taken into account: sex, age, stage of the neoclassic process, scope of the surgical intervention on the larynx and lymph nodes of the neck, thyroid gland surgery and dose of irradiation given in Gy/T at the time of radiotherapy.