In vitro and in vivo evaluation of sandwich-like mesoporous silica nanoflakes as promising anticancer drug delivery system.

We present the new promising nanostructure- sandwich-like mesoporous silica nanoflakes synthesized on graphene oxide sheets core. In the first step biocompatibility of the nanoflakes with PEG and without functionalization in human fibroblast, melanoma and breast cancer cells was assessed. In order to define the cellular uptake in vitro and biodistribution in vivo the nanostructures were labelled with fluorescent dye.

[The role of microRNAs in the pathogenesis and progression of liver diseases].

MicroRNAs are short non-coding RNAs that regulate the expression of genes at the post-transcriptional level. They play a key role in a number of biological processes, including cell differentiation, immune response, apoptosis and metabolism regulation. They are also directly or indirectly involved in the development and progression of numerous diseases.

Propylparaben-induced disruption of energy metabolism in human HepG2 cell line leads to increased synthesis of superoxide anions and apoptosis.

The effect of propylparaben (in final concentrations 0.4 ng/ml, 2.3 ng/ml and 4.