Publications by authors named "S Szczesny"
Article Synopsis
- - The study investigates how tendon maturation into strong tissue is regulated, noting significant mechanical property changes in chick embryos between days E16 and E18, but lacking clarity on the underlying cellular and molecular factors.
- - Researchers analyzed late tendon development by examining collagen fiber alignment, cell organization, and Yap pathway activity, assessing the impact of both constant loading and no loading on tendon maturation.
- - Findings revealed that YAP signaling is influenced by movement, with collagen alignment improving under static loading; however, immobilization disrupted the organized structure of tendon cells, highlighting the importance of dynamic stimulation for proper tendon development.
Article Synopsis
- There is a significant increase in the mechanical properties and load-bearing capabilities of tendons during embryonic development, but the exact structural elements contributing to this growth are not fully understood.
- Researchers used various methods, including shear lag modeling and mechanical testing, to analyze the changes in tendon structure and function in embryonic chick development, revealing that increases in fibril length and crosslinking are key to enhanced mechanics.
- Inhibiting collagen crosslinking and inducing muscle paralysis demonstrated that both crosslink formation and fibril elongation are essential for developing strong load-bearing tendons and are sensitive to mechanical stimulation.
Anterior cruciate ligament (ACL) injuries are historically thought to be a result of a single acute overload or traumatic event. However, recent studies suggest that ACL failure may be a consequence of fatigue damage. Additionally, the remodeling response of ACLs to fatigue loading is unknown.
View Article and Find Full Text PDFCell encapsulation has been studied for various applications ranging from cell transplantation to biological production. However, current encapsulation technologies focus on cell protection rather than cell regulation that is essential to most if not all cell-based applications. Here we report a method for cell nanoencapsulation and regulation using an ultrathin biomimetic extracellular matrix as a cell nanocapsule to carry nanoparticles (CN ).
View Article and Find Full Text PDFSpiking neural networks (SNNs) are subjects of a topic that is gaining more and more interest nowadays. They more closely resemble actual neural networks in the brain than their second-generation counterparts, artificial neural networks (ANNs). SNNs have the potential to be more energy efficient than ANNs on event-driven neuromorphic hardware.
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