Publications by authors named "S Sylvester Darvin"
Non-alcoholic Fatty Liver Disease (NAFLD) is one of the growing epidemics of the globe. This study was aimed to evaluate the anti-NAFLD effect of selected IAN derivatives using in silico, in vitro and in vivo models. In silico tools viz.
View Article and Find Full Text PDFArticle Synopsis
- Increasing global interest in herbal health supplements for obesity is noted, with a focus on Spermacoce hispida L. seeds, traditionally used for obesity treatment in Tiruvallur district, Tamil Nadu, India.
- The study aimed to validate this traditional use and identify the active component with antihyperlipidemic properties through bioassay-guided fractionation, leading to the discovery of deacetylasperulosidic acid (DAA).
- DAA demonstrated significant antihyperlipidemic effects in experimental models, reducing lipid levels and adipocyte proliferation, thereby supporting its potential as a treatment for obesity and related conditions.
The Drug-induced liver injury is one of the common unfavourable impacts, which seriously affects any drug therapy. This study documented the hepatoprotective efficacy of lawsone, the major bioactive naphthoquinone present in Lawsonia inermis L. (Lythraceae) using in vitro and in vivo models.
View Article and Find Full Text PDFThe prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing and there is an increasing interest in natural products to treat NAFLD. This study aimed to evaluate the hepatoprotective effect of andrographolide and two of its derivatives; in one the OH group at C-14 was removed and in the other OH groups at C-3 and C-19 were protected. Andrographolide (AN) was isolated from the aerial parts of Andrographis paniculata Wall.
View Article and Find Full Text PDFThe gum of Gardenia resinifera Roth., is one of the important drugs used in the Indian system of medicine and a source of unique polymethoxylated flavones. This study was aimed to evaluate the antihyperlipidemic and anti-NAFLD effects of Gardenin A (Gar-A) from G.
View Article and Find Full Text PDF