Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model.

Background: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice.

Method: BM-M were transplanted into the tail vein and the animals analysed 1 month later.

Results: BM-M transplantation promoted the reduction of the amyloid beta [3742] plaque number and size in the cortex and hippocampus of the treated mice, but no change in the more heavily modified pyroglutamate amyloid beta E3 plaques.

Systematic Review of miRNA as Biomarkers in Alzheimer's Disease.

Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a progressive decline in cognitive impairment.

Host suppression and stability in a parasitoid-host system: experimental demonstration.

We elucidate the mechanisms causing stability and severe resource suppression in a consumer-resource system. The consumer, the parasitoid Aphytis, rapidly controlled an experimentally induced outbreak of the resource, California red scale, an agricultural pest, and imposed a low, stable pest equilibrium. The results are well predicted by a mechanistic, independently parameterized model.