Publications by authors named "S Suwazono"
Article Synopsis
- Myotonic dystrophy Type 1 (DM1) is linked to the expansion of CTG repeats in the DMPK gene and may be associated with heart issues and sudden death, but this relationship is not fully understood in Japan and Europe.
- A study analyzed 496 DM1 patients from nine Japanese hospitals, finding that those with 1300 or more CTG repeats had a significantly higher risk of serious cardiac events and mortality compared to those with fewer repeats.
- The results suggest that patients with 1300 or longer CTG repeats are particularly at risk for cardiac complications and increased death rates, while the rate of sudden death was not significantly different across groups.
Article Synopsis
- A study analyzed data from the Pompe Registry to evaluate how higher doses of alglucosidase alfa (ALGLU) affect survival rates in infants with infantile-onset Pompe disease (IOPD).
- Out of 332 IOPD patients studied, those who received doses higher than the standard label dose (20 mg/kg every two weeks) showed significantly better survival outcomes and less need for invasive ventilation.
- The findings suggest that administering a higher average dose of ALGLU could lead to improved overall survival in IOPD patients, regardless of their age at treatment onset or immune status.
Article Synopsis
- The study explores the effectiveness of ear canal electroencephalogram (EEG) recordings, demonstrating that they can produce comparable and distinct event-related potentials (ERPs) when using a specific experimental method.
- Results showed that ear canal EEG recordings detected clear auditory ERPs, particularly the N1c component, which was more pronounced at the ear canal site than at the earlobe despite similarities in consecutive signals.
- Although the study's sample size was small and limited to male participants, it suggests that this ear canal electrode method can be useful for both basic research and practical applications in EEG measurement and behavioral feedback assessments.
Background: Myotonic dystrophy type 1 (DM1) is a form of muscular dystrophy that causes various symptoms, including those of the central nervous system. Some studies have reported cognitive decline in patients with DM1, although the available evidence is limited.
Objective: This study aimed to describe longitudinal differences in neuropsychological function in patients with DM1.
Background: We hypothesised that the radiomics signature, which includes texture information of dopamine transporter single-photon emission computed tomography (DAT-SPECT) images for Parkinson's disease (PD), may assist semi-quantitative indices. Herein, we constructed a radiomics signature using DAT-SPECT-derived radiomics features that effectively discriminated PD from healthy individuals and evaluated its classification performance.
Results: We analysed 413 cases of both normal control (NC, n = 101) and PD (n = 312) groups from the Parkinson's Progression Markers Initiative database.