YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.

Certain environmental toxins and chemotherapeutics are nucleic acid-damaging agents, causing adducts in DNA and RNA. While most of these adducts occur in RNA, the consequences of RNA damage are largely unexplored. Here, we demonstrate that nuclear RNA damage can result in loss of genome integrity in human cells.

Thermodynamic Hydricity of a Ruthenium CO Hydrogenation Catalyst Supported by a Rigid PNP Pincer.

Ruthenium hydride complexes supported by pincer ligands play a crucial role in the catalytic hydrogenation of CO to reduced C chemicals such as formic acid and methanol. Toward a better understanding of their hydride transfer reactivity, knowledge of the underlying thermodynamic hydricity values is deemed critical, but relevant studies remain rare. Herein, we report the experimental thermodynamic hydricity of a new ruthenium CO hydrogenation catalyst (PNP)RuH(CO)(PPh) () supported by a rigid, acridane-based PNP pincer ligand.

Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma.

The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% of liver cancers, poses a significant health burden. The effectiveness of traditional hepatocellular carcinoma treatments such as surgical resection, radiotherapy, and chemotherapy is limited, underscoring the need for innovative therapeutic strategies. To this end, we synthesized phthalyl-pullulan nanoparticles encapsulating IR780 (an NIR-responsive heptamethine cyanine dye) and R848 (resiquimod; a TLR7/8 agonist) (PIR NPs).

Brayton-Moser passivity based controller for constant power load with interleaved boost converter.

A DC microgrid with renewable energy sources can achieve reduced current ripple, higher efficiency, faster dynamics, high voltage gain, and less operational stress by interfacing with an interleaved boost converter (IBC). The stability of an IBC linked to a DC microgrid supplying a constant power load (CPL) can be imperceptibly guaranteed by a conventional controller. A tightly regulated CPL with nonlinear and negative incremental impedance characteristics will lead to stability issues.