Single nucleotide polymorphism and lifestyle-related diseases in the Asia-Pacific region: comparative study in Okinawa, Palau and Thailand.

Genetic differences between Asians and Caucasians may be involved in the rapid increase in lifestyle-related diseases in the Asia-Pacific region that has coincided with Westernisation of diets in the region. In the present study, we assessed correlation between 10 single nucleotide polymorphisms (SNPs) and chronic disease risk factors in age-matched and population-based groups in four Asian-Pacific locations: Okinawa, Palau and Thailand (two areas). The following allelic SNP profiles significantly differed (p<0.

Leptin resistance conferred by a combination of single nucleotide polymorphism and the adoption of a Western lifestyle in urban areas of Thailand.

Objectives: An increasing number of lifestyle disorders have emerged in response to the rapid urbanization that has occurred in Thailand. Recently, leptin resistance has been nominated as a possible marker for the onset of metabolic disorders in Asian countries. The research aimed to assess the relationship between leptin-resistance and environmental and/or genetic factors by comparing urban and rural inhabitants in Thailand.

A survey of life-style diseases of inhabitants of Thailand.

To elucidate the way to prevent lifestyle-related diseases, such as diabetes mellitus and hypertension, in Asian countries, a comparative study between Mongoloids was conducted at Palau, in Oceania, the Republic of China, Thailand, Mongolia and Japan, from 1998 to October 2002. The survey comprised a social survey, nutrition survey, physical and medical examinations, biomedical analyses, urinalyses, and DNA analyses. This is an interim report for Thailand.