Publications by authors named "S Sunderam"
The neuronal ceroid lipofuscinoses (NCLs) are a group of recessively inherited neurodegenerative diseases characterizsed by lysosomal storage of fluorescent materials. CLN3 disease, or juvenile Batten disease, is the most common NCL that is caused by mutations in the Ceroid Lipofuscinosis, Neuronal 3 (CLN3) gene. Sleep disturbances are among the most common symptoms associated with CLN3 disease that deteriorate the patients' life quality, yet this is understudied and has not been delineated in animal models of the disease.
View Article and Find Full Text PDFBrain-computer interfaces (BCIs) offer disabled individuals the means to interact with devices by decoding the electroencephalogram (EEG). However, decoding intent in fine motor tasks can be challenging, especially in stroke survivors with cortical lesions. Here, we attempt to decode graded finger extension from the EEG in stroke patients with left-hand paresis and healthy controls.
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- * Researchers used transcriptome data from two different genotypes of B. juncea, identifying 1,539 lncRNAs and analyzing their expression patterns, leading to selecting 25 lncRNA candidates linked to seed traits like size and oil content, along with 28 regulatory networks.
- * A new database, the BrassIca juncea database (BIJ), was created to provide accessible seed omics and genomic data, aiding future crop improvement efforts through molecular breeding and genome editing based on the identified lnc
Accumulation of amyloid-β (Aβ) plays an important role in Alzheimer's disease (AD) pathology. There is growing evidence that disordered sleep may accelerate AD pathology by impeding the physiological clearance of Aβ from the brain that occurs in normal sleep. Therapeutic strategies for improving sleep quality may therefore help slow disease progression.
View Article and Find Full Text PDFBackground: Sleep perturbation is widely used to investigate the physiological mechanisms that mediate sleep-wake dynamics, and to isolate the specific roles of sleep in health and disease. However, state-of-the-art methods to accomplish sleep perturbation in preclinical models are limited in their throughput, flexibility, and specificity.
New Method: A system was developed to deliver vibro-tactile somatosensory stimulation aimed at controlled, selective sleep perturbation.