Publications by authors named "S Sundararaj"
Harnessing solar energy can be efficiently used to generate hydrogen by photochemical water splitting, which is a sustainable and environmentally benign energy source. Here, a unique visible-light-driven CoTiO@g-CN (CTOCN)-based photoanode interface has been optimized and developed with modification to follow the type II heterojunction for the enhancement of photoelectrochemical water splitting. Initially, a graphitic carbon nitride-loaded CoTiO (with 10 wt % g-CN) composite was obtained using a one-pot solvothermal method.
View Article and Find Full Text PDFA 38-year-old woman with papillary carcinoma of the thyroid who underwent total thyroidectomy followed by high-dose radioiodine ablation was called for Iodine-131 (I-131) whole-body follow-up scan. Her follow-up scan revealed focal tracer accumulation in the lower aspect of the right posterior neck region. Her stimulated serum thyroglobulin and anti-thyroglobulin antibodies were 0.
View Article and Find Full Text PDFArticle Synopsis
- A specific mutation in the IRF4 gene, associated with classic Hodgkin lymphoma, alters the protein's ability to bind to DNA, changing its normal functions.
- This mutation leads to a loss of typical interactions with certain DNA motifs while allowing new, atypical DNA binding interactions.
- The findings reveal how one mutation can significantly change the behavior of a transcription factor, potentially offering targeted treatment strategies that inhibit its abnormal activity.
Transcutaneous auricular Vagus Nerve Stimulation and Median Nerve Stimulation reduce acute stress in young healthy adults: a single-blind sham-controlled crossover study.
Front Neurosci
September 2023
Stress is a major determinant of health and wellbeing. Conventional stress management approaches do not account for the daily-living acute changes in stress that affect quality of life. The combination of physiological monitoring and non-invasive Peripheral Nerve Stimulation (PNS) represents a promising technological approach to quantify stress-induced physiological manifestations and reduce stress during everyday life.
View Article and Find Full Text PDFA multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Sci Immunol
January 2023
Article Synopsis
- - Researchers discovered a recurrent mutation in the IRF4 gene, identified as p.T95R, linked to an autosomal dominant combined immunodeficiency (CID) in seven patients from six different families, leading to severe vulnerability to opportunistic infections and low antibody levels.
- - The mutation caused significant defects in the maturation of B cells and alterations in T cell populations, resulting in impaired immune responses, as demonstrated in both human patients and a knock-in mouse model with similar symptoms.
- - The altered IRF4 protein exhibited unusual behaviors, including stronger DNA binding but reduced activity on typical target genes, while also activating noncanonical genes, showcasing a complex interaction that disrupts normal immune function and leads to disease.