Nuclear PD-L1 triggers tumour-associated inflammation upon DNA damage.

Immune checkpoint inhibitors against PD-1/PD-L1 are highly effective in immunologically hot tumours such as triple-negative breast cancer, wherein constitutive DNA damage promotes inflammation, while inducing PD-L1 expression to avoid attack by cytotoxic T cells. However, whether and how PD-L1 regulates the DNA damage response and inflammation remains unclear. Here, we show that nuclear PD-L1 activates the ATR-Chk1 pathway and induces proinflammatory chemocytokines upon genotoxic stress.

Optical hyperdimensional soft sensing: speckle-based touch interface and tactile sensor.

Hyperdimensional computing (HDC) is an emerging computing paradigm that exploits the distributed representation of input data in a hyperdimensional space, the dimensions of which are typically between 1,000-10,000. The hyperdimensional distributed representation enables energy-efficient, low-latency, and noise-robust computations with low-precision and basic arithmetic operations. In this study, we propose optical hyperdimensional distributed representations based on laser speckles for adaptive, efficient, and low-latency optical sensor processing.

Novel missense variants cause intermediate phenotypes in the phenotypic spectrum of SLC5A6-related disorders.

SLC5A6 encodes the sodium-dependent multivitamin transporter, a transmembrane protein that uptakes biotin, pantothenic acid, and lipoic acid. Biallelic SLC5A6 variants cause sodium-dependent multivitamin transporter deficiency (SMVTD) and childhood-onset biotin-responsive peripheral motor neuropathy (COMNB), which both respond well to replacement therapy with the above three nutrients. SMVTD usually presents with various symptoms in multiple organs, such as gastrointestinal hemorrhage, brain atrophy, and global developmental delay, at birth or in infancy.

Functional evaluation of BRCA1/2 variants of unknown significance with homologous recombination assay and integrative in silico prediction model.

Numerous variants of unknown significance (VUSs) exist in hereditary breast and ovarian cancers. Although multiple methods have been developed to assess the significance of BRCA1/2 variants, functional discrepancies among these approaches remain. Therefore, a comprehensive functional evaluation system for these variants should be established.

Analysis of temporal structure of laser chaos by Allan variance.

Allan variance has been widely utilized for evaluating the stability of the time series generated by atomic clocks and lasers, in time regimes ranging from short to extremely long. This multiscale examination capability of the Allan variance may also be beneficial in evaluating the chaotic oscillating dynamics of semiconductor lasers- not just for conventional phase stability analysis. In the present study, we demonstrated Allan variance analysis of the complex time series generated by a semiconductor laser with delayed feedback, including low-frequency fluctuations (LFFs), which exhibit both fast and slow dynamics.