Publications by authors named "S Summermatter"
Article Synopsis
- - Multiple sclerosis (MS) is an autoimmune disease causing inflammation and damage in the central nervous system, leading to symptoms like muscle dysfunction that can affect mobility and quality of life.
- - Current treatments mainly focus on neuroinflammation, leaving a need for therapies targeting muscle function, as many people with MS experience skeletal muscle issues that can precede mobility-related disabilities.
- - Exercise, particularly aerobic and resistance training, is highlighted as an effective intervention to improve muscle strength, reduce fatigue, and enhance overall well-being in individuals with MS, emphasizing the importance of implementing these exercises early on.
Article Synopsis
- Musculoskeletal diseases are a major cause of mobility issues, often linked to muscle weakness, making resistance training a common treatment to boost strength.
- This study examines the chemerin pathway's role in inflammation and muscle function, finding that blocking a specific receptor (CMKLR1) can temporarily enhance strength but reduces endurance in mice.
- The research highlights the importance of CMKLR1 in muscle regeneration and contractility, suggesting potential for new drugs targeting this pathway to treat musculoskeletal and other diseases.
Article Synopsis
- Age-related loss of motor neurons affects muscle function, but the exact cause is still not well understood.
- Research on mice shows that neurotoxic microglia in the spinal cord play a role in this decline, as changes in motor units occur before muscle function decreases.
- Voluntary exercise and depleting harmful microglia can prevent or reverse this decline, suggesting that targeting these microglia might help maintain muscle health in aging.
Article Synopsis
- * Researchers created specific inhibitors targeting HDAC4 and uncovered three new proteins it modifies: myosin heavy chain, PGC-1α, and Hsc70, which play roles in muscle structure and metabolism.
- * Blocking HDAC4 can prevent muscle degradation and enhance metabolic pathways, hinting at potential new treatments for muscle disorders and other related diseases.
Mouse models of cancer-induced cachexia: Hind limb muscle mass and evoked force as readouts.
Biochem Biophys Res Commun
September 2018
Article Synopsis
- Advanced cancer patients commonly experience cachexia, a condition that leads to significant muscle loss and affects their treatment response, quality of life, and survival chances.
- There are currently no effective treatments for cachexia, highlighting the urgent need for early detection and monitoring of muscle mass loss to implement timely interventions.
- The study introduces simpler experimental cancer models using mice and human cancer cells, allowing for easier observation of muscle deterioration and evaluation of potential therapies for cachexia.