Publications by authors named "S Sulfaro"
Article Synopsis
- Head and Neck Squamous Cell Cancer (HNSCC) is a significant health concern, ranking sixth among global cancers, with a pressing need for new therapies and biomarkers due to slow advancements in treatment personalization.!* -
- This study analyzed the somatic mutations in 15 specific genes related to HNSCC in a high-incidence area of Italy, finding unique mutation patterns that may have prognostic implications, particularly in the hypopharyngeal region.!* -
- The research revealed that while certain mutations indicate poorer prognosis, they currently lack sufficient evidence to be used as predictive biomarkers, highlighting the necessity for further studies to improve treatment options for HNSCC patients.!*
Background: Neoadjuvant chemotherapy (NACT) is widely used in the treatment of triple-negative and HER2-positive breast cancer (BC), but its use in estrogen receptor (ER) and/or progesterone receptor (PR) positive/HER2-negative BC is questioned because of the low pathologic complete response (pCR) rates. This retrospective study assessed the mRNA-based MammaTyper® assay's capability of predicting pCR with NACT, and ER, PR, Ki67, and HER2 status at immunohistochemical (IHC) through transcriptomics.
Methods: Diagnostic biopsies from 76 BC patients treated at the Cremona Hospital between 2012-2018 were analyzed.
Angiosarcoma (AS) represents a rare and aggressive vascular sarcoma, posing distinct challenges in clinical management compared to other sarcomas. While the current European Society of Medical Oncology (ESMO) clinical practice guidelines for sarcoma treatment are applicable to AS, its unique aggressiveness and diverse tumor presentations necessitate dedicated and detailed clinical recommendations, which are currently lacking. Notably, considerations regarding surgical extent, radiation therapy (RT), and neoadjuvant/adjuvant chemotherapy vary significantly in localized disease, depending on each different site of onset.
View Article and Find Full Text PDFBackground And Purpose: Currently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse and improved survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). However, a subset of HPV-positive OPSCC patients still experience poor outcomes. Furthermore, HPV-negative OPSCC patients, who have an even higher risk of relapse, are still lacking suitable prognostic biomarkers for clinical outcome.
View Article and Find Full Text PDFEBUS-Guided Cryobiopsy of Mediastinal Lymphonodes: The First Case Report.
J Bronchology Interv Pulmonol
October 2022