Publications by authors named "S Sugahara"
Article Synopsis
- Thallium (Tl) is a toxic heavy metal, and recent studies focus on its effects in the kidneys, revealing notable molecular mechanisms related to its toxicity.
- In an experiment, rats were given Tl2SO4, and analysis showed that ribosomal proteins were significantly upregulated, indicating increased ribosome production and protein translation in response to Tl exposure.
- However, mitochondrial biogenesis declined, with a disruption in the signaling pathway of Myc, suggesting a failure to coordinate ribosomal and mitochondrial responses during Tl toxicity in the kidneys.
Article Synopsis
- Thallium (Tl) is a highly toxic heavy metal linked to accidental poisoning and can cause severe health issues including kidney failure.
- In a study on rats, intraperitoneal administration of Tl led to significant kidney dysfunction, characterized by high calcium deposits and mitochondrial issues in a specific kidney region called the medullary thick ascending limb (mTAL).
- The research found that inhibiting a specific kidney transporter helped reduce Tl accumulation and its damaging effects, which could lead to new treatment strategies for Tl poisoning and improve diagnostic methods for related kidney damage.
Spinal angiolipomas are rare benign tumors composed of mature adipose cells and blood vessel walls. We report the case of a patient with a spinal epidural angiolipoma who presented with paraplegia and was treated by urgent tumor resection and decompression. The patient was a 79-year-old man who presented to our hospital with a 6-month history of numbness in both lower limbs.
View Article and Find Full Text PDFGlobal proliferative arrest (GPA) is a phenomenon in monocarpic plants in which the activity of all aboveground meristems generally ceases in a nearly coordinated manner after the formation of a certain number of fruits. Despite the fact that GPA is a biologically and agriculturally important event, the underlying molecular mechanisms are not well understood. In this study, we attempted to elucidate the molecular mechanism of GPA regulation by identifying the gene responsible for the Arabidopsis mutant fireworks (fiw), causing an early GPA phenotype.
View Article and Find Full Text PDFWe have clinically implemented gated stereotactic body radiotherapy under abdominal compression using an Anzai laser-based gating device with visual guidance in combination with an Elekta linear accelerator. To ensure accuracy, we configured the gating window for each patient by correlating the respiratory curve from the laser sensor and the tumor positions from the 4D computed tomography (CT) images reconstructed with the aid of the respiratory curve. This allowed us to define a patient-specific gating window to keep the tumor displacement below 5 mm from the end-expiration, assuming the reproducibility of the tumor trajectories and the laser-based body surface measurements.
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