Construction of a hydrazine electrochemical sensor using Ag@ZIF as the electrode material.

In recent years, the fabrication of hydrazine sensors has received extensive attention because of the toxicity of hydrazine to the environment and human beings. It is thus important to design and develop efficient electrode modifiers for the construction of hydrazine electrochemical sensors. Herein, we reported the benign synthesis of a silver (Ag)-doped zinc-based zeolitic imidazolate framework (ZIF-8).

Amyloid Targeting-Gold Nanoparticles-Assisted X-ray Therapy Rescues Islet β-Cells from Amyloid Fibrils and Restores Insulin Homeostasis.

Type-2-diabetes is a metabolic disorder where misfolding and oligomerization of islet amyloid polypeptide (IAPP) around islet-β cells oligomerizes and participates in the pathology. The oligomeric stage is toxic but transitory and leads to the formation of mature amyloid fibrils. The pathological specifics of mature amyloid fibrils are poorly understood.

Mitigating cadmium stress in rice (Oryza sativa L.) using succinic and oxalic acids with focus on cellular integrity and antioxidant responses.

Soil contamination with toxic heavy metals [such as cadmium (Cd)] is becoming a serious global problem due to the rapid development of the social economy. Organic chelating agents such as succinic acid (SA) and oxalic acid (OA) are more efficient, environmentally friendly, and biodegradable compared to inorganic chelating agents and they enhance the solubility, absorption, and stability of metals. To investigate this, we conducted a pot experiment to assess the impact of SA (0.

Modelling assisted phytoextraction of heavy metals from tannery origin leachate.

The toxic tannery solid waste leachate (TSWL) containing heavy metals is generated after the percolation of rainwater in openly dumped tannery solid waste (TSW) which poses a serious threat to the surroundings by leaching down and bioaccumulation. For its management, the phytoextraction potential of Pistia stratiotes L. and Spirodela polyrhiza L.

Combating sepsis-induced acute lung injury: PARP1 inhibition mediates oxidative stress mitigation and miR-135a-5p/SMAD5/Nanog axis drives regeneration.

Purpose: The purpose of this study was to investigate the therapeutic potential of Poly (ADP-ribose) polymerase 1 (PARP1) inhibition combined with microRNA miR-135a-5p overexpression in sepsis-induced acute lung injury (ALI). Specifically, we aimed to elucidate combinatorial therapeutic potential of PARP1 inhibition in mitigating oxidative stress and inflammation across different models, simultaneously miR-135a-5p overexpression promoting regeneration through the SMAD5/Nanog axis.

Method: We used C57BL/6 mice to create Cecal Ligation Puncture (CLP) model of Sepsis-induced Acute Lung Injury.