Publications by authors named "S Subbanna"
Article Synopsis
- - Cannabis sativa contains over 120 phytocannabinoids, with Δ-THC and CBD being the most recognized, but many lesser-known compounds are showing potential in affecting health through interactions with the endocannabinoid system.
- - These compounds can cross the blood-brain barrier and have antioxidant, anti-inflammatory, and neuro-modulatory properties that might help in treating neurodegenerative diseases.
- - While Δ-THC has been studied for its neuroprotective effects, there is increasing interest in non-psychotropic minor phytocannabinoids, which could offer therapeutic benefits for brain disorders and deserve more research.
Recent genomics and epigenetic advances have empowered the exploration of DNA/RNA methylation and histone modifications crucial for gene expression in response to stress, aging and disease. Interest in understanding neuronal plasticity's epigenetic mechanisms, influencing brain rewiring amid development, aging and neurodegenerative disorders, continues to grow. Histone acetylation dysregulation, a commonality in diverse brain disorders, has become a therapeutic focus.
View Article and Find Full Text PDFEthanol exposure in neonatal mice induces acute neurodegeneration followed by long-lasting glial activation and GABAergic cell deficits along with behavioral abnormalities, providing a third trimester model of fetal alcohol spectrum disorders (FASD). Retinoic acid (RA), the active form of vitamin A, regulates transcription of RA-responsive genes and plays essential roles in the development of embryos and their CNS. Ethanol has been shown to disturb RA metabolism and signaling in the developing brain, which may be a cause of ethanol toxicity leading to FASD.
View Article and Find Full Text PDFBT75, a boron-containing retinoid, is a novel retinoic acid receptor (RAR)α agonist synthesized by our group. Previous studies indicated that activation of retinoic acid (RA) signaling may attenuate progression of Alzheimer's disease (AD). Presently, we aimed to examine the anti-inflammatory effect of BT75 and explore the possible mechanism using cultured cells and an AD mouse model.
View Article and Find Full Text PDFArticle Synopsis
- Synaptic plasticity refers to the brain's ability to strengthen or weaken synaptic connections, playing a crucial role in brain remodeling after various types of damage, including alcohol use disorders (AUDs).
- While significant research has focused on synaptic plasticity, its influence on neurobehavioral issues in AUDs, particularly in relation to fetal alcohol spectrum disorder (FASD), is still not fully understood.
- Recent studies suggest that prenatal alcohol exposure leads to synaptic and molecular changes that could serve as targets for new treatments to improve cognitive and behavioral outcomes in individuals affected by FASD.