Publications by authors named "S Strittmatter"

Article Synopsis
  • A study was conducted to investigate the X-chromosome's role in Alzheimer's Disease (AD), which had been overlooked in previous genome-wide association studies.
  • The research included 115,841 AD cases and 613,671 controls, considering different X-chromosome inactivation (XCI) states in females.
  • While no strong genetic risk factors for AD were found on the X-chromosome, seven significant loci were identified, suggesting areas for future research.
View Article and Find Full Text PDF
Article Synopsis
  • Selecting the right genes to identify different cell types is crucial in single-cell sequencing analysis, but existing methods often lead to redundancy and lack specificity in gene expression patterns.* -
  • CosGeneGate is a new model that improves the selection of marker genes by focusing on both the accuracy of cell-type classification and the unique expression patterns of the genes.* -
  • Tests show that CosGeneGate identifies better-performing non-redundant marker genes across major human cell types and tissues, with results available on their GitHub page.*
View Article and Find Full Text PDF

Amyloid accumulation in Alzheimer's disease (AD) is associated with synaptic damage and altered connectivity in brain networks. While measures of amyloid accumulation and biochemical changes in mouse models have utility for translational studies of certain therapeutics, preclinical analysis of altered brain connectivity using clinically relevant fMRI measures has not been well developed for agents intended to improve neural networks. Here, we conduct a longitudinal study in a double knock-in mouse model for AD (App/hMapt), monitoring brain connectivity by means of resting-state fMRI.

View Article and Find Full Text PDF

Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins has been associated with neurodegenerative diseases, although direct mechanisms are poorly defined. Here, we report on a maturation process for the cellular prion protein (PrP) that involves a conformational change after LLPS and is regulated by mutations and poly(4-styrenesulfonic acid--maleic acid) (PSCMA), a molecule that has been reported to rescue Alzheimer's disease-related cognitive deficits by antagonizing the interaction between PrP and amyloid-β oligomers (Aβo). We show that PSCMA can induce reentrant LLPS of PrP and lower the saturation concentration () of PrP by 100-fold.

View Article and Find Full Text PDF
Article Synopsis
  • - TMEM106B is a protein linked to various neurological disorders such as frontotemporal dementia and Alzheimer's, and it's being studied for its potential involvement in COVID-19.
  • - Research revealed that mice lacking TMEM106B showed reduced levels of key myelin lipids, specifically galactosylceramide and sulfatide, indicating a role in lipid metabolism.
  • - The study found that TMEM106B interacts with the enzyme galactosylceramidase, which was more active in the absence of TMEM106B, suggesting it plays a crucial role in regulating myelin lipids relevant to related diseases.
View Article and Find Full Text PDF