Publications by authors named "S Strassburg"
Background/objectives: Recent studies indicate that sleep and sleep disorders differ between men and women, but corresponding data in people with chronic lung diseases are lacking. This study aims to answer the question of what the sex-specific differences in sleep profiles and responses to elexacaftor/tezacaftor/ivacaftor (ETI) therapy in people with cystic fibrosis (pwCF) are.
Methods: Adult pwCF and a matched control group (adults with suspected sleep-disordered breathing undergoing in-laboratory polysomnography (PSG)) were included.
Cystic fibrosis bone disease (CFBD) is a common comorbidity in adult people with cystic fibrosis (pwCF), resulting in an increased risk of bone fractures. This study evaluated the capacity of artificial intelligence (AI)-assisted low-dose chest CT (LDCT) opportunistic screening for detecting low bone mineral density (BMD) in adult pwCF. In this retrospective single-center study, 65 adult pwCF (mean age 30.
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- Poor nutritional status negatively impacts lung function and survival in people with cystic fibrosis (pwCF).
- A study using deep-learning analyzed body composition changes in 66 adults with CF before and after elexacaftor/tezacaftor/ivacaftor (ETI) therapy, finding significant increases in adipose tissue but only minimal improvements in muscle ratio.
- The results indicate that ETI therapy mainly influences fat tissue, particularly in underweight patients, which may inform future nutritional strategies for managing CF.
Article Synopsis
- Cystic fibrosis (CF) is characterized by immune dysregulation and chronic inflammation, and this study focused on the effects of the CFTR modulator therapy elexacaftor/tezacaftor/ivacaftor (ETI) on associated inflammation in patients with CF.
- Researchers analyzed plasma samples from 51 patients before, three months, and six months after starting ETI therapy, measuring various pro-inflammatory chemokines.
- Results showed significant improvements in lung function and decreases in specific inflammatory markers, particularly those linked to neutrophilic inflammation, indicating ETI's anti-inflammatory effects.
Article Synopsis
- The study investigates the personality traits of adult patients with cystic fibrosis (CF) and their relationship to health-related quality of life (HRQoL) and clinical severity indicators.
- Seventy adults completed specific questionnaires, revealing that CF patients displayed varying personality traits compared to the norm, with two distinct personality clusters identified based on their scores.
- Results indicate that psychological factors, particularly personality, significantly affect HRQoL in CF patients, suggesting that those with pronounced personality traits could benefit from psychosocial support to improve their quality of life.