[Bilateral lymphoblastic lymphoma of the breast].

A 21-year-old female patient presenting with bilateral lymphoblastic lymphoma of the breast was given two four-week courses of cytostatic therapy using the ALL/AUL protocol. Radiation therapy was used as an adjunct. Treatment resulted in tumour regression.

Glucocorticoid receptor level, terminal deoxynucleotidyl transferase activity and initial responsiveness to prednisone and vincristine in leukemia.

We have investigated glucocorticoid receptor (GR) level, terminal deoxynucleotidyl transferase (TdT) activity and the initial responsiveness to prednisone and vincristine in 31 patients with acute lymphatic leukemia (ALL) and with chronic myelogenous leukemia in blast transformation (CML/BT). All 11 patients with low levels of GR (5,000 binding sites per cell) were resistant to this initial treatment whereas 13 of the 20 patients with high levels of GR responded readily. The correlations between clinical responsiveness and TdT activity were significant to the p less than 0.

Capping of lymphocytes for carrier detection in Duchenne muscular dystrophy: technical problems and a review of the literature.

There has been considerable interest in capping of lymphocytes in patients with Duchenne muscular dystrophy (DMD). However, the results from different authors are controversial. We have investigated cap formation in thirteen families with DMD, using a method standardized in our laboratory, and could establish diminished capping in all 12 patients and in 12 of the 13 mothers.

Capping of lymphocytes in patients and carriers of Duchenne muscular dystrophy.

Recent results showed that Duchenne muscular dystrophy is probably associated with a generalized membrane defect. The capping phenomenon in lymphocytes indicates normal intramembrane protein mobility and disturbances of this phenomenon are is believed to reflect membrane alterations. We have investigated capping in lymphocytes from 19 patients with Duchenne muscular dystrophy, 13 carriers, 8 patients' sisters, 14 patients' aunts and 52 normal controls.