Methaemoglobinemia after Liposuction under Tumescent Local Anaesthesia - Diagnostic Value of Pulse Oximetry.

Background: Tumescent local anaesthesia with prilocain can lead to clinically significant methemoglobin levels. New generation multiple wavelength pulse oximeters (e. g.

Evaluation and application of a high performance liquid chromatographic method for prilocaine analysis in human plasma.

Background: Prilocaine, a local anesthetic of the amide type, is frequently applied in substantial doses during tumescent liposuction. Although it cannot be excluded that the subcutaneously infiltrated narcotic may enter the circulation and trigger adverse systemic reactions, prilocaine plasma levels have rarely been measured during routine tumescent surgery. We established and evaluated a high performance liquid chromatography (HPLC) method for analysis of this narcotic and used it to measure the drug in plasma samples drawn in the course of tumescent liposuction with prilocaine local anesthesia.

[Health reporting at the community level in Germany: results of a survey].

Aim: There is a lack of empirical research on communal health reporting in Germany. The aim of the "Munich Health Reporting Study" was to provide an overview of the spread, topics and data sources of communal health reporting as well as its integration into political decision making processes.

Methods: A questionnaire survey was carried out on all German health authorities.

Bipodal 1,1'-acyl-3,3,3',3'-tetraalkylbis(thiourea) ligands with flexible C3, C4 and C6 spacer groups.

In the structures of 3,3,3',3'-tetraethyl-1,1'-(propane-1,3-diyldicarbonyl)bis(thiourea), C(15)H(28)N(4)O(2)S(2), (I), 3,3,3',3'-tetraethyl-1,1'-(butane-1,4-diyldicarbonyl)bis(thiourea), C(16)H(30)N(4)O(2)S(2), (II), and 3,3,3',3'-tetrabutyl-1,1'-(hexane-1,6-diyldicarbonyl)bis(thiourea), C(26)H(50)N(4)O(2)S(2), (III), compound (I) displays resonance-assisted hydrogen bonding, (II) exhibits an inversion centre, and both (II) and (III) are characterized by intermolecular hydrogen bonds between the carbonyl O atoms and thioamide H atoms, leading to chains of hydrogen-bonded molecules throughout the structures. The accurate structural data for these molecules is expected to assist in molecular modelling and other studies currently in progress.